性酸酶正常化在拉丁裔患者中发生的频率较低,这些患者患有初级胆道胆道炎
Paul Yoon1, Adriana Shen1, Matthew Chen1
1Keck School of Medicine of USC, Los Angeles, CA, United States.
概括
拉美裔和非白人患有原发性胆道胆炎 (PBC) 的患者,不太可能通过ursodeoxycholic acid (UDCA) 治疗实现性酸酶 (ALP) 正常化. 解决这些服务不足的人群对治疗反应的差异对于最佳结果至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床研究 临床研究
- 生物化学 生物化学
背景情况:
- 性酸酶 (ALP) 的正常化是初级胆道胆炎 (PBC) 的关键治疗目标.
- 人种和种族差异的治疗反应的ursodeoxycholic 酸 (UDCA) 并没有很好地理解,特别是在西班牙裔人口.
研究的目的:
- 评估在PBC患者中使用UDCA实现完全生化缓解 (CBR) 的种族和民族差异.
- 专门研究洛杉矶东部拉丁语PBC (ELLA-PBC) 队列中西班牙裔人口的治疗结果.
主要方法:
- 使用PBC诊断的AASLD标准对ELLA-PBC队列 (2006-2022) 的回顾性分析.
- 卡普兰-梅尔方法用于无移植生存 (TFS) 和脱补偿事件 (DE).
- 多变量后勤回归用于评估UDCA启动后与1年CBR (ALP ≤1 × ULN) 相关的因素.
主要成果:
- 西班牙裔和非白人患者 (77.5%) 与非西班牙裔白人 (NHW) 患者 (22.5%) 相比较.
- 在种族/族群之间没有观察到5年TFS或DE的显著差异.
- 一年后,西班牙裔 (13.8%) 和非白人 (13.2%) 患者的CBR率明显低于NHW患者 (41.4%),调整后的几率比率分别为0.31和0.23.
结论:
- 与NHW患者相比,患有PBC的西班牙裔和非白人患者的CBR (ALP正常化) 实现率明显较低.
- 这些差异仍然存在,尽管可比的基线ALP水平.
- 在服务不足的人群中识别和解决UDCA治疗反应的障碍对于在PBC中实现最佳治疗目标至关重要.
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