对子宫内膜癌的新欧洲风险分类的评估:一个队列研究
Mikko Loukovaara1, Annukka Pasanen2, Ralf Bützow3
1Helsinki University Hospital and University of Helsinki, Department of Obstetrics and Gynecology, Helsinki, Finland; Helsinki University Hospital and University of Helsinki, Comprehensive Cancer Center, Helsinki, Finland.
概括
2025年子宫内膜癌风险分类将10.5%的患者重新分类,影响辅助治疗决策. 新系统虽然具有预测性,但与2021年系统相比,在区分某些风险群体方面存在局限性.
科学领域:
- 妇科瘤学 妇科瘤学
- 病理学 病理学 病理学
- 分子诊断学 分子诊断
背景情况:
- 欧洲妇科瘤学会 (ESGO),欧洲放射治疗和瘤学会 (ESTRO) 和欧洲病理学会 (ESP) 在2025年更新了子宫内膜癌风险分类.
- 这个新系统结合了新的病理和分子特征.
研究的目的:
- 评估2025年子宫内膜癌风险分类的临床影响和预后性能.
- 为了将2025年系统与2021年建立的分类进行比较.
主要方法:
- 回顾性单中心队列研究.
- 用2021年和2025年风险系统对患者进行分类.
- 免疫组织化学和POLE测序用于分子分类和雌激素受体状态.
主要成果:
- 分析了1115名患者,其中10.5%通过2025年系统重新分类.
- 这两种系统都显示出预后值 (p < .001).
- 2025年系统没有区分高中期和高风险疾病 (p > .15),而2021年系统则区分了无进展生存 (p = .026).
- 淋巴结的参与在分子瘤类别之间有显著的差异 (p < .001).
结论:
- 2025年ESGO-ESTRO-ESP分类对大约10%的患者的影响辅助治疗.
- 雌激素受体负性的稀有性限制了其在无特定分子配置分层中的实用性.
- 在分子亚型中观察到的淋巴结参与的变化表明了个性化手术分期的潜力.
更多相关视频
相关概念视频
Heart Failure IV: Classification and Diagnostic Evaluation
388
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
388
Relative Risk
2.1K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.1K
Force Classification
2.4K
Forces play a crucial role in the study of physics and engineering. They are essential in describing the motion, behavior, and equilibrium of objects in the physical world. Forces can be classified based on their origin, type, and direction of action.
Contact and non-contact forces are two of the most widely used categories of forces. As the name suggests, contact forces require physical contact between two objects to act upon each other. Examples of contact forces include frictional,...
Contact and non-contact forces are two of the most widely used categories of forces. As the name suggests, contact forces require physical contact between two objects to act upon each other. Examples of contact forces include frictional,...
2.4K
Classification of Neurotransmitters
5.3K
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
5.3K
Classification of Leukocytes
5.8K
Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
5.8K
Classification of Illness
8.7K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
8.7K


