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Updated: Feb 2, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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由于SLC46A1缺乏而导致的叶酸限制,通过表观遗传转录重编程抑制了结直肠癌的进展

Yelu Zhou1, Yanxing Liu1, Yi Liu2

  • 1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.

Cell death & disease
|January 31, 2026
PubMed
概括

叶酸转运体SLC46A1通过维持DNA甲基化来抑制结肠直肠癌 (CRC). 它在CRC中的降低调节会损害叶酸的吸收,导致DNA低甲基化和激活瘤基因,推动瘤的进展.

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