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Updated: Feb 2, 2026

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向甘氨酸脂生物合成克服化学抵抗驱动的SLFN11损失在尤文肉瘤的目标

Kasturee Chakraborty1, Ritambhar Burman1, Saharsh Satheesh1

  • 1Department of Radiology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Cell death & disease
|January 31, 2026
PubMed
概括

尤文肉瘤 (EWS) 中SLFN11表达的减少导致代谢变化,导致化学抵抗. 准糖脂生物合成可以恢复敏感性,为EWS提供了一个新的治疗策略.

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