在稳定的精神分裂症患者中探索代谢异常和多维认知障碍之间的复杂相互作用
Xiao Wang1,2, Jing Dang1,2,3, Xin Yu4
1Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
Translational psychiatry
|January 31, 2026
概括
代谢综合征的组成部分,如失脂症和高血压,与精神分裂症患者的认知缺陷有关. 管理高血压可能会改善这一群体的认知功能和社会结果.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 精神分裂症 (PWS) 患者常有认知缺陷.
- 代谢综合征 (MetS) 可能会在PWS中恶化认知障碍.
- 需要澄清MetS组件与认知功能障碍之间的准确联系.
研究的目的:
- 研究PWS中单个MetS组件和多维认知功能障碍之间的关联.
- 探索代谢指标在临床症状和认知功能之间的关系中的调解作用.
- 通过机器学习验证MetS组件对认知结果的预测效用.
主要方法:
- 一项对727名临床稳定的PWS患者的多中心研究.
- 使用中国简要认知测试 (C-BCT) 评估认知功能.
- 使用了网络分析,结构方程建模 (SEM) 和机器学习.
主要成果:
- 脱脂症 (DL) 和高血压 (HT) 与认知缺陷有显著的相关性.
- 患有两个或两个以上MetS组件 (MetS-2+) 的患者表现出明显的网络模式.
- DL和HT调解了临床症状和认知功能之间的关系.
- 机器学习模型有效地预测了基于MetS组件的认知维度.
结论:
- 特定的MetS组件,特别是DL和HT,与稳定的PWS中的认知功能密切相关.
- 在PWS中,HT的管理可能提供一种用于认知增强和改善社会功能的策略.
- MetS组件是精神分裂症多维认知结果的重要预测因素.
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