血蛋白质介导了空气污染暴露与疾病风险之间的关联
Wenran Li1, Kaixuan Li1, Puchen Zhou1
1Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Nature communications
|January 31, 2026
概括
空气污染通过循环蛋白质影响健康,影响免疫和代谢途径. 一个新的空气污染蛋白质风险评分 (APPRS) 有助于对与空气质量相关的疾病进行个性化风险评估.
科学领域:
- 环境健康 环境健康
- 蛋白质组学是指蛋白质组学.
- 系统生物学 系统生物学
背景情况:
- 空气污染是一个重要的全球健康风险,与许多疾病有关.
- 生物机制,特别是循环蛋白质的作用,尚未完全理解.
- 对空气污染对健康影响的个体敏感性需要进一步调查.
研究的目的:
- 系统地调查循环中的蛋白质如何调解空气污染对健康的影响.
- 确定与空气污染相关疾病有关的特定蛋白质和途径.
- 开发和验证个性化易感性评估的风险评分.
主要方法:
- 利用大规模的英国生物库数据,将空气污染暴露与疾病和循环蛋白联系起来.
- 采用统计分析来识别介导蛋白和途径.
- 在多个队伍中开发和验证了空气污染蛋白风险评分 (APPRS).
主要成果:
- 确定了30种与空气污染暴露显著相关的疾病.
- 发现了1089种与污染物相关的蛋白质,其中296种介导疾病风险,富含免疫通路.
- 介导途径因疾病类型而异 (例如,MAPK信号用于心血管,先天免疫对于免疫障碍).
- 在全球范围内,蛋白质组调解了空气污染与疾病相关性的23.69%.
- 开发的APPRS证明了与疾病风险的强有力的关联以及改进的预测模型.
结论:
- 循环蛋白质在调解空气污染对健康的影响方面发挥着核心作用.
- 已识别的调解途径突出显示了疾病特异性机制.
- APPRS是个性化风险评估和对空气污染暴露的精确公共卫生干预的宝贵工具.
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