基于社区的长途COVID队列中的疲劳谱
Isabelle V Carter1, Anna May2,3,4, Isabella C Hsieh2
1Department of Psychiatry, University Behavioral Health Care, Rutgers University Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Sleep & breathing = Schlaf & Atmung
|January 31, 2026
概括
后COVID疲劳呈现出一个频谱,其中21.9%符合肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 标准. 脑雾是长期COVID疲劳表现的一个明显特征,影响了临床试验.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 长期COVID转诊诊所对于了解SARS-CoV-2感染后的持续症状至关重要.
- 疲劳是长期COVID患者中很大一部分报告的主要和使人衰弱的症状.
- 描述疲劳表现对于准确诊断和管理后病毒综合征至关重要.
研究的目的:
- 描述长期COVID患者的主要疲劳表现.
- 根据对肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 的CDC 2015标准的遵守,比较疲劳特征.
- 在长期COVID患者群体中识别相关症状和导致疲劳的因素.
主要方法:
- 从2021年9月至2022年4月期间出现的277名长期COVID患者的临床数据分析.
- 根据ME/CFS标准,对有或没有主要疲劳症状的患者进行比较,并根据ME/CFS标准进行细分.
- 评估疲劳严重程度,身体功能 (ECOG),抑郁 (PHQ9),焦虑和脑雾.
主要成果:
- 73.5%的患者表现出疲劳,具有明显更高的疲劳严重性评分 (FSS) 在那些有主要疲劳投诉.
- 焦虑和一般精神病诊断在疲劳和ME/CFS标准的患者中过度表现.
- 21.9%的疲劳和高FSS患者符合ME/CFS的标准;脑雾与疲劳严重程度和身体功能相关.
结论:
- 长期COVID的疲劳表型是一个频谱,其中很大一部分不符合ME/CFS标准.
- 脑雾在长期COVID疲劳中呈现出明显的特征,需要进一步调查.
- 了解COVID后疲劳的异质性对于设计有效的临床试验和治疗策略至关重要.
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