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精神分裂症的有氧糖解:发育救援还是能量崩?

Onur Memetoglu¹, Manu S Goyal², Virginie-Anne Chouinard¹

¹McLean Hospital, Harvard Medical School, Belmont, MA, USA.

Molecular psychiatry

|January 31, 2026

概括

有氧糖解 (AG),一种代谢过程,在精神分裂症 (SZ) 中升高,可能是对大脑能量缺陷的补偿反应. 持续的AG可能会破坏大脑功能的稳定,提供新的治疗点.

科学领域:

神经科学是一个神经科学.
代谢生物学代谢生物学
精神病学是一个精神病学.

背景情况:

有氧糖解 (AG) 或华堡效应是一种新陈代谢过程,细胞优先使用糖解而不是氧化酸化 (OxPhos),即使有氧.
最初在癌细胞中观察到的AG现在被理解为一种更广泛的生理机制,支持生物合成,神经可塑性和协同生成.

研究的目的:

提出成人精神分裂症 (SZ) 的高AG反映了减少大脑生物质和线粒体功能障碍的补偿机制.
探索AG,受损的OxPhos,还原性压力和大脑中神经元-质合缺陷之间的联系.

主要方法:

对神经成像,光谱和死后研究的审查.
分析与能量恒温相关的寡细胞功能障碍和白质损伤.
对SZ的AG当前发现的基于前景的综合分析.

主要成果:

有证据表明,大脑中的AG与受损的OxPhos,还原性压力和受损的神经元-质相互作用有关.
寡细胞功能障碍和白质异常进一步破坏大脑的能量平衡和连接.
持久的AG虽然支持修复,但最终可能会破坏突触功能的稳定.

结论:

在SZ中的AG可能代表了对发育需求和成人代谢能力之间的不匹配的不适应反应.
了解AG在SZ中的持久性,可以确定恢复神经回路中的能量平衡的新策略.
向AG可能为精神分裂症提供新的治疗途径.

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