睡眠调节药物寻找和复发 - - 一个视角
Yu-Zhang Liu1,2, Hannah Rose Martin2,3, Brant P Hasler2
1Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Molecular psychiatry
|January 31, 2026
概括
睡眠障碍在物质使用障碍 (SUD) 中越来越多地被认可,可能提供新的治疗目标. 了解睡眠睡眠的理解
科学领域:
- 神经科学是一个神经科学.
- 睡眠科学 睡眠科学
- 成研究 研究成研究
背景情况:
- 睡眠障碍是物质使用障碍 (SUD) 中常见的并发症.
- 睡眠问题可能在SUD中起因作用,并呈现治疗点.
- 睡眠中的个体差异为生物标志物和个性化医学提供了潜力.
研究的目的:
- 审查睡眠障碍在物质使用障碍中的作用.
- 在SUD中检查受睡眠丧失影响的神经递质系统.
- 要总结与药物暴露和戒断相关的睡眠变化.
主要方法:
- 关于睡眠和SUD的最新研究的文献综述.
- 专注于神经递质和神经调节器系统.
- 在药物暴露和戒断后对睡眠变化的分析.
主要成果:
- 睡眠不足会影响寻求回报的行为,增加SUD风险.
- 急性和长期的药物暴露显著改变睡眠模式.
- 通过睡眠调节谷氨酸,多巴胺和类系统在SUD中至关重要.
结论:
- 睡眠障碍是SUD病理生理学的组成部分.
- 针对睡眠机制为SUD治疗提供了一个有希望的途径.
- 对睡眠作用的进一步研究可以推进个性化的SUD疗法.
相关概念视频
Drug Regulation
3.0K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
3.0K
Insufficient Sleep and Sleep Deprivation
938
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
938
Psychodynamic Perspectives on Personality
1.6K
The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
Psychodynamic theorists argue that unconscious...
1.6K
Stages of Sleep
1.4K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.4K
Understanding Sleep
1.6K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.6K
Sleep Apnea
559
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
559


