饮食中的酸通过调节微生物组-代谢物-免疫轴来抑制胃肠道病原体
Li-Na Mei1, Jia-Shan Shen1, Yu Duan1
1Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650500, People's Republic of China.
Natural products and bioprospecting
|January 31, 2026
概括
埃拉基酸有助于抗生素后肠道微生物群的恢复,减少有害细菌,如抗万科胺素耐药性肠球菌 (VRE). 这种食补充剂可以预防与抗生素相关的肠道疾病.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 抗生素破坏肠道微生物群,增加对感染的易感性,如抗万科胺素抗性肠球菌 (VRE).
- 在水果和坚果中发现的酸具有多种生物活性,但缺乏直接的抗菌特性.
研究的目的:
- 研究基酸对肠道微生物群恢复和抗生素治疗后病原体过度生长的影响.
- 探索埃拉基酸影响肠道健康和调节炎症通路的机制.
主要方法:
- 给患有抗生素诱导的肠道失调症的小鼠施用酸.
- 分析肠道微生物群的组成,多样性和病原体水平.
- 研究G蛋白结合受体 (Gpr41,Gpr43) 和NF-κB信号通路的激活.
主要成果:
- 酸促进了肠道微生物群的恢复,并增强了微生物的多样性.
- 它刺激了有益的益生菌微生物的增殖,并改善了病原体的过度生长.
- 酸通过短链脂肪酸 (SCFA) 激活了Gpr41和Gpr43,抑制了NF-κB信号通路.
结论:
- 饮食中的酸可以恢复肠道微生物群的平衡,并在使用抗生素后对抗病原体的扩散.
- 埃拉基酸的机制涉及SCFA的产生,Gpr41/Gpr43的激活和NF-κB通路的抑制.
- 埃拉基酸为与抗生素相关的肠道疾病提供了一个新的治疗策略,也是药物发现的新途径.
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