高风险软组织瘤在老年患者:外科手术期间的放射疗法改善局部控制和预后吗?
Tomohiro Fujiwara1, Toshiharu Mitsuhashi2, Yutaka Nezu3
1Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan. tomomedvn@okayama-u.ac.jp.
BMC cancer
|January 31, 2026
概括
术后放射治疗 (RT) 没有改善老年软组织肉瘤 (STS) 患者的生存率. 然而,辅助性RT在老年STS患者中降低了局部复发,边缘较小,这表明量身定制的方法可能是有益的.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 辐射瘤学 辐射瘤学
背景情况:
- 晚年与软组织肉瘤 (STS) 患者的较差结果有关.
- 优化老年STS患者的治疗非常重要,因为现实数据有限.
- 在高风险的老年STS患者中,术后放射治疗 (RT) 的作用需要澄清.
研究的目的:
- 评估术后放射治疗 (RT) 对患有高风险软组织肉瘤 (STS) 的老年患者疾病特异性生存期 (DSS) 和局部复发 (LR) 的影响.
主要方法:
- 对1,214名老年患者 (≥70岁) 进行了回顾性分析,这些患者有局部,高度,深层的STS (≥5厘米).
- 排除患有小圆细胞STS,状脂肉瘤或接受术前化疗或术后RT的患者.
- 倾向性得分匹配用于比较接受和不接受外科手术期间RT的患者之间的结果.
主要成果:
- 在整体队列中,术后RT并没有显著影响疾病特异性存活率 (DSS).
- 辅助RT与减少局部复发 (LR) 相关,这些患者具有内伤口或边缘边缘.
- 在倾向性得分匹配队列中的组之间没有观察到DSS或LR的显著差异.
结论:
- 周术RT与老年高风险STS患者的整体生存率改善或局部复发减少无关.
- 辅助性RT可以通过减少局部复发,使老年STS患者具有内伤或边缘边缘受益.
- 需要进行进一步的前性试验,以确定外科手术期间RT在这个患者群体中的确切作用.
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