探索多草药组合治疗疼痛和炎症的治疗潜力
Maryam Anis1, Sadia Ghousia Baig2, Umbreen Farrukh3
1Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
Pakistan journal of pharmaceutical sciences
|February 1, 2026
概括
这项研究表明,Boswellia serrata,Brassica nigra,Piper longum和Withhania somnifera具有镇痛和抗炎性质. 它们的组合显著增强了这些效果,为疼痛和炎症管理提供了强大的草药替代品.
科学领域:
- 药理学 药理学是指药理学的学科.
- 民族植物学 民族植物学
- 自然产品化学 自然产品化学
背景情况:
- 疼痛和炎症是对受伤的关键生理反应,影响许多疾病.
- 现有的治疗疼痛和炎症的药理疗法具有局限性和不良影响.
- 民间医学使用Boswellia serrata,Brassica nigra,Piper longum和Withhania somnifera,因为它们的 analgesic和抗炎作用.
研究的目的:
- 评估四种药用植物的单独和联合止痛和抗炎作用.
- 在体内调查 Boswellia serrata,黑,Piper longum 和 Withania somnifera 提取物的疗效.
- 探索一种潜在的草药治疗替代方案来治疗疼痛和炎症.
主要方法:
- 植物提取物被口服给瑞士白色老鼠和Wistar白色老鼠,剂量为400和800毫克/公斤.
- 用尾部浸泡,热板和酸诱导的曲试验来评估镇痛活性.
- 使用卡拉诱导的脚胀模型评估抗炎活性;急性毒性也被评估.
主要成果:
- 在高达3000mg/kg的急性毒性研究中没有观察到死亡率.
- 与对照组相比,单个植物提取物表现出显著的剂量依赖的止痛和抗炎作用 (p < 0.05).
- 多草药组合表现出高度显著的止痛和抗炎作用 (p < 0.001),超过单个提取物.
结论:
- 每种研究的植物都具有固有的止痛和抗炎性质.
- 博斯韦利亚,黑,长和Withhania somnifera的组合显示出增强的治疗疗效.
- 这种多草药配方代表了治疗疼痛和炎症的有希望和有效的天然替代品.
关键词:
止痛药是一种止痛药.抗炎药物 抗炎药物 抗炎药物波斯韦利亚塞拉塔 Boswellia serrata黑 (Brassica nigra) 是一种黑 (Brassica nigra) 植物.长 (Piper longum) 是一种长.这种植物叫Withhania somnifera.更多相关视频
04:48Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
Published on: November 22, 2024
850
09:38Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
Published on: April 14, 2016
13.2K
相关概念视频
Inflammation
62.1K
Overview
62.1K
Pain
1.4K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.4K
The Resting Membrane Potential
142.5K
Overview
142.5K
Therapeutic Index
6.8K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.8K
Potential Energy
42.7K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.7K
Standard Electrode Potentials
50.3K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.3K
