CD8/CD4比率,CD56和PD-L1作为鼻粘膜黑色素瘤的预后标志物
Chiau-Sheng Jang1, I-Chieh Chuang2
1Department of Dermatology, Kaohsiung Veterans General Hospital, No. 386, Dazhong 1St Rd., Zuoying District, Kaohsiung City, 813414, Taiwan. macemars@gmail.com.
International journal of clinical oncology
|February 1, 2026
概括
免疫标记物,如CD8到CD4淋巴细胞比率和CD56阳性淋巴细胞,在鼻腔粘膜黑色素瘤 (SNMM) 中具有预后价值. 这些发现可能有助于改善风险分层,并指导SNMM的向治疗.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 鼻粘膜黑色素瘤 (SNMM) 是一种具有很少预后标记的侵袭性癌症.
- 识别新的标志物对于更好的患者结果至关重要.
研究的目的:
- 调查免疫标记物 (CD8 / CD4比率,CD56 + 淋巴细胞,PD-L1) 是否在SNMM中提供预后信息.
- 评估这些标志物是否能改善现有的临床病理因素.
主要方法:
- 67名经过手术治疗的SNMM患者的回顾性审查.
- 对CD8/CD4比率,CD56+淋巴细胞和PD-L1表达的免疫组织化学分析.
- 使用卡普兰-梅尔和考克斯比例危险模型进行生存分析.
主要成果:
- 增加的CD8/CD4比率和CD56+淋巴细胞与更好的疾病特异性生存率 (DSS) 相关联.
- PD-L1阳性与较短的无复发生存时间 (RFS) 有关.
- 高线粒活性和PD-L1阳性独立预测了更糟糕的结果,而CD8/CD4比率预测了改善的DSS.
结论:
- 免疫标记物,特别是CD8/CD4比率和CD56+淋巴细胞,显著影响SNMM的存活率.
- 免疫分析可以提高SNMM的风险分层.
- 这些发现可能有助于开发针对SNMM的免疫向疗法.
关键词:
CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD7 CD7 CD7 CD7 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9这是一种CD56抗原.这是一个CD8比率.透的淋巴细胞.连接物1 连接物1黑色素瘤是一种黑色素瘤.编程死亡是一种被编程死亡.瘤是一个瘤.更多相关视频
相关概念视频
PD Controller: Design
655
In automotive engineering, car suspension systems often employ Proportional Derivative (PD) controllers to enhance performance. PD controllers are utilized to adjust the damping force in response to road conditions. A controller, acting as an amplifier with a constant gain, demonstrates proportional control, with output directly mirroring input.
Designing a continuous-data controller requires selecting and linking components like adders and integrators, which are fundamental in Proportional,...
Designing a continuous-data controller requires selecting and linking components like adders and integrators, which are fundamental in Proportional,...
655
Mucosal Barrier of the Stomach
2.3K
The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
2.3K
Poisson's Ratio
1.1K
Poisson's ratio is a material property that indicates their stress response. It explains the connection between the elongation or compression a material undergoes in the direction of an applied force and the contraction or expansion it experiences perpendicular to that force. When a slender bar is loaded axially, it stretches in the direction of the force and contracts laterally. Poisson's ratio is the negative ratio of this lateral contraction to the axial elongation. The negative sign...
1.1K
Odds Ratio
1.9K
The odds ratio (OR) is a statistical measure used extensively in epidemiology and research to quantify the strength of association between exposure and outcome across different groups. Unlike relative risk, which compares the probabilities of an event occurring, the odds ratio compares the odds of an event occurring in the exposed group to the odds of it occurring in the unexposed group. The odds, in this context, are calculated as the probability of the event happening divided by the...
1.9K
Hazard Ratio
606
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
606
Time-Domain Interpretation of PD Control
406
Proportional-Derivative (PD) control is a widely used control method in various engineering systems to enhance stability and performance. In a system with only proportional control, common issues include high maximum overshoot and oscillation, observed in both the error signal and its rate of change. This behavior can be divided into three distinct phases: initial overshoot, subsequent undershoot, and gradual stabilization.
Consider the example of control of motor torque. Initially, a positive...
Consider the example of control of motor torque. Initially, a positive...
406


