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Updated: Feb 3, 2026

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在超大尺寸的腺相关病毒载体中对基因组截断模式的定量分析

Yifan Yang1, Dongxin Wang1, Yun Yuan1

  • 1Suzhou Institute of Biomedical Engineering and Technology, CAS No.88, Keling Road, Suzhou, 215163, Jiangsu, People's Republic of China.

Biotechnology letters
|February 1, 2026
PubMed
概括

腺相关病毒 (AAV) 载体包装截断了大型基因组,显著的DNA损失发生在4.5kB以上. 这影响了基因疗法载体设计和记者基因表达.

关键词:
在ITR中,它是ITR.这就是RAAV RAAV.单极性的单极性在TRS中,可以使用TRS.截断的 截断的

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