装有复星的多 (乳酸) /多 (氨酸) 纳米粒子:抗氧化潜力和生物相容性
Daianne Leandro Padroni de Souza1, Lívia Rodrigues de Menezes1
1Instituto de Macromoléculas Professora Eloisa Mano - Av. Horácio Macedo, Universidade Federal do Rio de Janeiro, Ilha do Fundão, RJ, Brazil.
Journal of biomaterials science. Polymer edition
|February 1, 2026
概括
聚合物纳米粒子有效地稳定了强有力的抗氧化剂白醇,用于局部使用. 这些聚氨酸涂层的纳米粒子保持了复星的活性和生物相容性,显示了护肤应用的前景.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 药理学 药理学是指药理学的学科.
背景情况:
- 复星是一种多,具有强大的抗氧化特性,但由于溶解性和稳定性差,在局部配方中面临挑战.
- 聚合物纳米颗粒提供了一个有前途的解决方案,以提高像白醇这样的不溶性化合物的输送和有效性.
研究的目的:
- 开发和描述涂有聚氨酸的聚D,L-乳酸 (PLA) 纳米颗粒,以改善复星的输送.
- 评估含有白醇的纳米颗粒的物理化学性质,抗氧化活性和细胞相容性.
主要方法:
- 使用纳米沉方法制备纳米颗粒,具有不同的白醇负载 (5%,10%,15%).
- 特性包括粒子大小,形态,泽塔潜力,封装效率,里埃变换红外光谱 (FTIR),热重力测量分析 (TGA) 和抗氧化剂测定 (DPPH).
- 使用L929纤维细胞和HaCaT角质细胞评估了细胞兼容性.
主要成果:
- 在长达六个月的时间里,PLA纳米颗粒表现出球形形态 (100-150nm) 和高体稳定性.
- 封装效率从84%降至62%随着白醇负载的增加.
- 含有白醇的纳米颗粒保持了抗氧化活性,并显示出出色的细胞相容性 (>95%的细胞活力).
结论:
- 聚氨酸涂层的PLA纳米粒子有效地增强了复星的物理化学稳定性,同时保持了其抗氧化能力和生物相容性.
- 配方含有5%和10%的复星负载,在潜在的局部应用中显示出最有利的整体性能.
更多相关视频
09:02Using Polystyrene-block-polyacrylic acid-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization
Published on: July 9, 2015
12.8K
09:31Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
Published on: November 5, 2016
7.7K
相关概念视频
Amino acids
105.5K
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...
105.5K
Standard Electrode Potentials
50.3K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.3K
Potential Energy
42.7K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.7K
Impact Loading
699
Impact loading occurs when a moving object collides with a stationary structure, such as a rod with a uniform cross-sectional area fixed at one end. Under these conditions, the rod absorbs the kinetic energy from the striking object, leading to deformation and subsequent stress development. As the rod returns to its original position and reaches maximum stress, the absorbed energy, initially manifested as kinetic energy, transforms entirely into strain energy.
In cases of elastic deformation,...
In cases of elastic deformation,...
699
Distributed Loads
973
Distributed loads are a common type of load that engineers and scientists encounter in various practical situations. Distributed loads often refer to a type of load spread over a surface or a structure and can be modeled as continuous force per unit area.
For example, consider a bookshelf filled with books stacked vertically adjacent to each other. The weight of the books is evenly distributed over the length of the shelf. As a result, the pressure at different locations on the surface of the...
For example, consider a bookshelf filled with books stacked vertically adjacent to each other. The weight of the books is evenly distributed over the length of the shelf. As a result, the pressure at different locations on the surface of the...
973
Eccentric Loading
965
Eccentric loading is a crucial concept in the study of structural engineering and mechanics, particularly when analyzing the stability and stress distribution in columns. Unlike centric loading, where the force is applied along the centroidal axis, causing uniform compression, eccentric loading occurs when a force is applied off-center. This off-center application introduces not only direct compressive stress but also bending stress, significantly influencing the column's behavior under...
965
