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Updated: Feb 3, 2026

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通过生理学基础的药理动力学-药理动力学模型在猪中优化蒂尔米可辛的剂量对抗Pasteurella multocida

Lei Sun1,2, ChengYang Zhang1,2, Kun Mi1,2

  • 1Department of Veterinary Medicine Science, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China.

Journal of agricultural and food chemistry
|February 1, 2026
PubMed
概括

优化蒂尔米科辛剂量对猪呼吸系统疾病至关重要,因为细菌耐药性不断增加. 一个新的基于生理学的药理动力学-药理动力学 (PBPK-PD) 模型建议使用3天的治疗方案来提高疗效和预防耐药性.

关键词:
在P. multocidacida中发现了多种类型.提尔米科辛是一种有毒的药物.剂量方案 剂量方案基于生理学的药理动力学-药理动力学模型.禁食时间间隔.

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