在胃癌中,CCR1作为免疫反应激活与抑制表型的决定性因素的作用
Keran Sun1, Jingyuan Ning1, Keqi Jia2
1Department of Immunology, School of Basic Medical Sciences, Hebei Medical University, Shijiazhuang, Hebei, China; Key Laboratory of Immune Mechanism and Intervention for Major Diseases of Hebei, Shijiazhuang, Hebei, China.
概括
在胃癌中,基因基因受体1 (CCR1) 表达与患者生存时间的延长有关. 巨细胞上的CCR1通过CXCL9/CXCL10促进T细胞透,影响瘤的进展.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 化学基因受体1 (CCR1) 在癌症免疫力中的作用尚不清楚,特别是在胃癌中.
- 了解CCR1的功能对于胃癌免疫微环境的表征至关重要.
研究的目的:
- 研究CCR1在胃癌进展中的作用.
- 为了确定CCR1是否促进或抑制瘤的发展.
主要方法:
- 使用了转录组分析,临床数据相关性和生存分析.
- 在体内进行了CCR1-Knockout模型和巨细胞耗尽实验.
- 采用了西式涂抹,qRT-PCR,免疫光,单细胞和空间转录学.
主要成果:
- 高CCR1表达与显著更长的患者存活时间相关.
- 在胃癌中,CCR1主要表达在与瘤相关的巨细胞 (TAMs) 上.
- 巨细胞中CCR1缺乏会损害T细胞的透,增加瘤的生长.
结论:
- 巨细胞上的CCR1通过CXCL9/CXCL10信号增强了T细胞的招募.
- 通过调节T细胞分布,CCR1在胃癌中起着保护作用.
- CCR1代表了胃癌治疗的潜在治疗标.
相关概念视频
Humoral Immune Responses
83.9K
Overview
83.9K
Role of Hematopoietic Growth Factors
3.9K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
3.9K
Active versus Passive Immunity
10.8K
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
10.8K
Cell-mediated Immune Responses
84.1K
Overview
84.1K
Cells of the Adaptive Immune Response
8.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.9K
Immune Response Against Viral Pathogens
2.0K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
2.0K


