皮层厚度与过去一年的情绪发作有关,主要的抑郁和双相情感障碍
Kayla A Mackenzie1, Ashley A Heywood2, Jinhyeong Bae3
1Alfred Mental and Addiction Health, Alfred Health, Melbourne, Australia.
Psychiatry research. Neuroimaging
|February 1, 2026
概括
大型抑郁症和双相情绪障碍中最近的情绪发作与特定大脑区域皮质厚度增加有关. 这一发现表明皮层厚度可能作为最近情绪发作的一个生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 重度抑郁症 (MDD) 和双相情感障碍 (BD) 是显著的情感障碍.
- 与最近情绪发作相关的结构性大脑变化尚未得到充分理解.
- 研究对大脑结构的急性影响对于理解这些疾病至关重要.
研究的目的:
- 为了比较皮质厚度在成年人和没有最近的心情情节.
- 在MDD和BD患者中识别与情绪发作相关的急性结构性大脑变化.
- 为了探索最近情绪发作的潜在生物标志物.
主要方法:
- 在30名符合DSM-5MDD或BD标准的成年人中比较皮质厚度.
- 将参与者分为过去一年情绪事件 (PYME) 组 (n=18) 和非PYME组 (n=12).
- 在前一年中使用结构性MRI和临床评估 (HAM-D,YMRS,LIFE访谈).
主要成果:
- 小型企业小组在左侧中间轨道前皮层中显示出较大的皮质厚度.
- 在PYME组中,双边V1,左边V3,右边V2视觉皮层和双边海马/左侧前皮层中观察到皮层厚度增加.
- 这些差异在与没有最近情绪发作的人相比,在最近情绪发作的人群中观察到.
结论:
- 最近的情绪发作与皮层厚度增加相关.
- 这种增加可能表明急性补偿性炎症反应.
- 皮层厚度显示出作为近期情绪发作的跨诊断生物标志物的潜力,即使是在euthymic患者中.
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