一种鱼VNAR-IL-15融合蛋白抑制TROP2瘤生长

Zhongqiu Wu1, Hao Li2, Yanqing Wang3

  • 1Research Center for Deepsea Bioresources (Sanya), Hainan, 572025, China; School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.

概括

一种新型的融合蛋白质通过鱼衍生的抗体向TROP2表达瘤输送Interleukin-15 (IL-15). 这种有针对性的方法通过局部激活免疫细胞来增强癌症免疫疗法,减少全身毒性并抑制瘤生长.

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