睡眠质量与炎症性肠病中的疾病活性之间的关联:系统性审查和元分析
Shizhan Chen1, Chengmin Yu2, Fei Fang2
1Department of Medical Affairs, The Third Affiliated Hospital of Zhejiang Chinese Medical University(Zhongshan Hospital of Zhejiang Province), Hangzhou, Zhejiang, China.
概括
睡眠质量差与活跃的炎症性肠病 (IBD) 有关. 然而,证据有限,反向因果关系是可能的. 需要更多的研究来证实IBD患者的这种关联.
科学领域:
- 胃肠病学 胃肠病学
- 睡眠医学 睡眠医学
- 临床研究 临床研究
背景情况:
- 炎症性肠病 (IBD) 包括诸如克罗恩病和性结肠炎等慢性疾病.
- 睡眠障碍在IBD患者中很常见,可能会影响疾病活动.
- 了解睡眠质量和IBD活动之间的关系对于患者管理至关重要.
研究的目的:
- 系统地审查和分析证据,将睡眠质量差与炎症性肠病 (IBD) 中的活跃疾病联系在一起.
主要方法:
- 在PubMed,Embase,Scopus和Web of Science数据库中进行了全面的文献搜索,直到2025年7月15日.
- 20项主要是横截面的研究被纳入了元分析.
- 匹兹堡睡眠质量指数是评估睡眠质量的最常见工具.
主要成果:
- 分析显示,睡眠质量差和IBD活跃之间存在显著的关联 (OR:2.54).
- 这种关联在克罗恩病中是显著的,但在性结肠炎中没有.
- 结果在横截面研究中具有意义,但在前性队列研究中没有,这表明证据质量的潜在局限性.
结论:
- 目前的证据,主要来自横截面研究,表明睡眠质量差和活跃的IBD之间存在联系.
- 由于研究设计的局限性,不能排除活性疾病影响睡眠的逆因果关系的可能性.
- 需要进一步进行高质量的前性研究,才能确定确切的因果关系.
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