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Updated: Feb 3, 2026

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揭示人类T细胞受体生殖系多样性:335个新型单基因在47个使用gAIRR套件的Pangenome参考个体中被确定

Yu-Hsuan Yang1, Chi-Yuan Yao2, Mao-Jan Lin3

  • 1Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan.

Journal of advanced research
|February 1, 2026
PubMed
概括

这项研究显著扩大了人类T细胞受体 (TR) 生殖系多样性,通过识别335个新型TR等位基因及其侧翼序列. 这些发现增强了免疫遗传关联研究,并支持多样化,独立于祖先的免疫疗法.

关键词:
适应性免疫受体谱 (AIRR) 是一种适应性免疫受体谱.表示的AIRR (exprAIRR)编码AIRR (gAIRR) 的生殖系基因组人类泛基因组参考联盟 (HPRC)免疫遗传学信息系统 (IMGT)免疫基因组学是什么一个新型的等位基因.T细胞受体 (TR) 是一种T细胞受体.V(D) J的重组组合.gAIRR套房是一间套房.

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