在基于认知努力的决策过程中神经激活:与退伍军人精神分裂症和双相情感障碍的退伍军人脱离的关联
Logan D Leathem1, Pooja K Patel1, Deanna M Barch2
1Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|February 1, 2026
概括
精神分裂症患者由于大脑活化减少而表现出基于努力的决策能力受损 (EBDM),与双相情感障碍患者不同,这表明动机缺陷的不同神经生物学基础.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 基于努力的决策 (EBDM) 对激励至关重要.
- 精神分裂症 (SZ) 和双相情感障碍 (BD) 表现出类似的EBDM缺陷,但在动机概况上有所不同.
- 不同的神经机制可能是这些动机差异的基础.
研究的目的:
- 调查SZ,BD和对照之间的EBDM中的功能性大脑差异.
- 确定SZ和BD中动机缺陷的神经相关性.
主要方法:
- 28名SZ,21名BD和30名控制参与者进行认知EBDM任务的fMRI扫描.
- 操纵奖励值以影响任务选择 (努力,容易或公正).
主要成果:
- 精神分裂症组在ACC,前部岛屿和dlPFC中减少了审议时间和低活化.
- 状体,vmPFC和PCC激活模式与SZ的动机缺陷相关,但不是BD.
结论:
- 精神分裂症的特征是EBDM关键大脑区域的低活化.
- 独特的神经行为过程有助于SZ和BD的动机缺陷,尽管有类似的行为EBDM障碍.
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