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在雷特综合征中剖析甲基胺基酸受体7表达:对药物治疗的后果

Sheryl Anne D Vermudez1, Geanne A Freitas1, Mackenzie Smith2

  • 1Department of Pharmacology and Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.

Neuroscience
|February 1, 2026
PubMed
概括

雷特综合征 (RTT) 与MECP2基因突变有关. 这项研究在RTT患者中发现了降低的甲基酸盐受体7 (mGlu7) 和mGlu7阳性全调节剂 (PAMs) 在小鼠模型中减少了呼吸问题.

关键词:
在MECP2中,MECP2是MECP2.甲基托类谷氨酸受体 甲基托类谷氨酸受体 甲基托类谷氨酸受体雷特综合征 雷特综合征mGlu ((7)) 的情况.

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