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腹部肥胖指标对家族高胆固醇血症全因死亡率的预后价值

Weida Liu¹, Runzhen Chen², Qi Li³

¹State Key Laboratory for Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Clinical nutrition ESPEN

|February 1, 2026

概括

身体形状指数 (ABSI) 和体重调整的腰部指数 (WWI) 预测了家族性高胆固醇血症 (FH) 患者的死亡率. ABSI提供卓越的预测价值,改善风险分层,为量身定制的FH管理提供优质预测价值.

科学领域:

心脏病学心脏病学
代谢健康代谢健康
流行病学流行病学

背景情况:

家族性高胆固醇血症 (FH) 是一种导致早发心血管疾病的遗传性疾病.
腹部肥胖指标越来越多地被认为是它们在各种健康状况中的预后价值.
确定可靠的FH患者死亡风险标志物对于有效管理至关重要.

研究的目的:

调查多个腹部肥胖指标与FH患者全因死亡率之间的关联.
为了比较这些指标在预测死亡风险方面的预后表现.
确定特定的肥胖指数是否可以改善FH的风险分层.

主要方法:

来自国家健康和营养检查调查 (NHANES) (1999-2018) 的1,188名FH患者队列的分析.
通过将其与2019年全国死亡指数联系起来,确定了死亡结果.
使用多变量Cox比例危险模型和增量预测价值评估 (C-统计,IDI,NRI).

主要成果:

随访时间8.4年的中位数显示有215例死亡 (18.1%).
身体形状指数 (ABSI) 和体重调整腰部指数 (WWI) 的升高与所有死因死亡风险的增加显著相关.
ABSI展示了最实质性的增量预测值,显著改善了歧视和风险重新分类.

结论:

ABSI和WWI是FH患者全因死亡率的独立预测指标.
ABSI表现出卓越的预后性能,增强了死亡风险分层,超出了既定的因素.
将ABSI纳入临床模型可以改善预后,并指导FH个性化管理策略.

关键词:

腹部肥胖症腹部肥胖症所有原因的死亡率.家庭性高胆固醇血症是什么?预测性表现的预测性表现.

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