关于2025年乙型肝炎病毒感染管理的ALEH立场声明
Mario Guimarães Pessoa1, Nelia Hernandez2, Graciela Castro Narro3
1Division of Gastroenterology and Hepatology, University of São Paulo School of Medicine, São Paulo, Brazil.; Viral Hepatitis Special Interest Group, Latin American Association for the Study of the Liver (ALEH).
Annals of hepatology
|February 1, 2026
概括
新指南旨在通过简化诊断和扩大治疗来消除拉丁美洲的慢性乙型肝炎 (HBV). 这些更新的重点是改善疫苗接种和查,以减少肝病和癌症的发生率.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 慢性乙型肝炎病毒 (HBV) 感染是全球肝硬化和肝癌的主要原因,特别是在拉丁美洲.
- 尽管有有效的疫苗,但HBV在该地区仍未得到充分诊断和治疗,原因是医疗保健的难以获得.
研究的目的:
- 提出更新的拉丁美洲肝脏研究协会 (ALEH) 针对HBV消除的指南,与世卫组织的目标保持一致.
- 简化HBV诊断,扩大治疗资格,并加强拉丁美洲的疫苗接种策略.
主要方法:
- 建议快速诊断测试和反射HBVDNA测试,以改善获得.
- 促进评估肝病严重程度的非侵入性方法.
- 扩大抗病毒治疗标准,包括显著纤维化,HBV DNA升高和并发感染的患者.
主要成果:
- 指导方针强调通过普遍查,孕产妇预防和新生儿疫苗接种来预防母婴传播.
- 建议在HBV感染个体中进行型肝炎病毒 (HDV) 的普遍测试.
- 这些建议支持更广泛地获得TDF,TAF和ETV等抗病毒药物.
结论:
- 更新的ALEH指南呼吁在HBV管理中实现去中心化,简化和公平.
- 这些战略对于实现到2030年在拉丁美洲消除HBV的目标至关重要.
- 解决诊断和治疗障碍对于该地区的公共卫生至关重要.
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