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在斋月间歇性禁食期间进行levothyroxine管理的预先时间:多中心随机对照试验

Reem M Alamoudi¹, Samah Nawar², Abdulrahman Almulla³

¹King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia; King Saud Bin Abdulaziz University for Health Sciences, Saudi Arabia; King Abdullah International Medical Research Center, Saudi Arabia.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

|February 1, 2026

概括

在斋月期间,在伊法塔和黎明前服用莱沃西 (LT4) 有效地维持了甲状腺的稳定性. 在两种LT4疗法之间,患者满意度和生物化学控制是可比的.

科学领域:

内分泌学在内分泌学.
代谢障碍代谢障碍代谢障碍
药理学药理学是指药理学的学科.

背景情况:

主要的甲状腺功能低下症需要持续的莱沃甲状腺素 (LT4) 管理.
斋月禁食对药物服用时间提出了挑战,可能会影响甲状腺激素水平.
在斋月期间优化LT4剂量对于患者的福祉和坚持至关重要.

研究的目的:

为了比较两个LT4剂量计划在斋月期间的疗效:伊法尔前和黎明前.
评估甲状腺生化控制 (TSH,FT4) 和患者对每种治疗方案的满意度.
在间歇性禁食期间为LT4管理提供基于证据的建议.

主要方法:

一个多中心的,开放的随机对照试验与成年甲状腺功能低下症患者进行.
参与者被随机分配在伊法尔 (断食) 或黎明前 (禁食前) 服用LT4.
甲状腺刺激激素 (TSH) 和自由甲状腺素 (FT4) 水平在斋月之前和之后被测量.

主要成果:

303名参与者完成了这项研究,在各组中具有可比的人口统计和并发症.
在斋月前和黎明前的LT4组之间,没有观察到斋月后TSH或FT4水平的显著差异.
甲状腺激素的群体内变化无意义,表明两种方案的稳定性.

结论:

伊法塔前和黎明前的LT4剂量方案在斋月期间保持甲状腺稳定性方面同样有效.
任何剂量策略都可以安全地实施,允许患者选择.
这些发现支持在遵守斋月的甲状腺功能低下患者灵活的LT4管理.

关键词:

利沃甲氧氨酸 (Levothyroxine) 是一种药物.有关RCT的RCT是什么斋月禁食斋月斋月禁食斋月在 TSH 中,您可以使用调节时间的时间.

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