对抗 antracycline 毒性的保护方法
Tsigereda Weldemichael1, Md Abdul Hye Khan1, John D Imig1
1Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Biochemical pharmacology
|February 1, 2026
概括
像多克索鲁比这样的癌症化疗药物可以损害脏,导致脏损伤和慢性脏病. 本综述探讨了多克索鲁比诱导的毒性机制,并讨论了改善化疗安全的潜在保护策略.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 化学疗法,包括多克索鲁比辛 (DOX),对于癌症治疗至关重要,但可能导致严重的损伤 (毒性).
- 化疗造成的损伤可以表现为急性损伤 (AKI) 和进展为慢性病 (CKD).
- doxorubicin 诱导的毒性涉及复杂的机制,包括氧化应激,炎症和亡,损害功能.
研究的目的:
- 审查多克索鲁比诱导的毒性机制.
- 强调在接受化疗的癌症患者中需要脏保护策略的需要.
- 讨论旨在减轻DOX相关脏损伤的新兴疗法.
主要方法:
- 对多克索鲁比辛毒性研究的文献综述.
- 分析包括氧化应激,炎症和亡在内的机制.
- 评估当前和正在研究中的脏保护剂和天然化合物.
主要成果:
- 多克索鲁比通过多因素途径损害脏,影响脏血管和脏结构.
- 现有证据表明氧化应激,炎症和亡是DOX诱导损伤的关键因素.
- 在临床前研究中,各种天然化合物和药理学剂在保护DOX毒性方面表现有前途.
结论:
- doxorubicin 诱导的毒性是一个严重的临床问题,需要有效的管理策略.
- 向氧化和炎症途径为开发脏保护疗法提供了一个有希望的方法.
- 对这些策略的进一步研究对于保持功能和提高基于多克索鲁比的化疗的安全性至关重要.
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