增强抗真菌治疗皮肤候群病:开发,评估和优化含有卢利可纳的转基因体凝
Mohamed A Akl1, Mahmoud M El-Sonbaty2, Tarek M Ibrahim3
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt.; Department of Pharmaceutics, College of Pharmacy, The Islamic University, Najaf 54001, Iraq.
Journal of pharmaceutical sciences
|February 1, 2026
概括
这项研究开发了一种新型的转基因凝 (LCZ-TEG) 用于卢利可纳 (LCZ) 治疗真菌性皮肤感染. 优化的凝增强了药物递送,显著提高了抗真菌疗效,减少了治疗时间.
科学领域:
- 皮肤病学和真菌学
- 制药和药物输送 制药和药物输送
- 材料科学 材料科学 材料科学
背景情况:
- 皮肤疹是一种常见的真菌感染,由Candida albicans引起,抗真菌耐药性增加使治疗复杂化.
- 卢利可纳 (LCZ) 是一种有效的抗真菌药物,具有不良的溶解性和穿透皮肤,限制其局部应用.
- 开发先进的药物输送系统对于克服这些局限性和提高治疗结果至关重要.
研究的目的:
- 为了制定和优化卢利可纳 (LCZ) 的转基因凝 (LCZ-TEG),以改善局部输送和对皮肤角膜病的疗效.
- 为了提高LCZ的溶解度和穿透皮肤,使用Transethosomal凝系统.
- 为了评估优化LCZ-TEG与自由LCZ和市场配方相比,优化LCZ-TEG的抗真菌功效.
主要方法:
- 用卢利可纳装载的转基因组 (LCZ-TES) 被准备并进行了表征.
- 转基因体凝 (LCZ-TEG) 使用基基甲基纤维素基制成,并通过Box-Behnken设计 (设计框架质量) 进行优化.
- 进行了ex vivo皮肤透,共聚焦激光扫描显微镜 (CLSM),体外抗真菌试验,以及在老鼠模型中的体内研究.
主要成果:
- 优化的LCZ-TEG配方表现出有利的特征:粒子大小 (111.90nm),PDI (0.072),ZP (+49.40mV) 和高捕获效率 (95.00%) 与持续释放.
- 活体研究和CLSM证实,LCZ-TES与自由LCZ相比,显著增强了LCZ-TES的皮肤透率和LCZ输送深度.
- 在体外和体内研究表明,对于LCZ-TEG,抑制区域增加1.40倍,治疗时间减少1.50倍.
结论:
- 开发的卢利可纳转菌体凝 (LCZ-TEG) 有效地提高了药物的溶解性,皮肤透性和抗真菌功效.
- LCZ-TEG显示出作为一种有效和向的局部治疗皮肤菌病的显著潜力,解决抗真菌耐药性带来的挑战.
- 这种配方代表了局部抗真菌药物输送系统的有希望的进步.
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