在有限阶段小细胞肺癌同时进行化学辐射治疗后,患者报告的结合杜尔瓦卢马布与安慰剂的结局:来自ADRIATIC第3期试验的结果
Silvia Novello1, Ying Cheng2, David Spigel3
1Department of Oncology, University of Turin, AOU San Luigi Gonzaga, Orbassano, Italy.
概括
在化疗放射治疗后巩固杜瓦卢马布并没有使有限阶段小细胞肺癌患者的生活质量恶化. 这支持杜尔瓦卢马布作为一种新的护理标准,改善生存率而不会损害患者的福祉.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 患者报告的结果
背景情况:
- 在ADRIATIC试验中,研究了在化学放射治疗后的有限阶段小细胞肺癌 (LS-SCLC) 中巩固杜瓦卢马布.
- 以前的分析表明,杜尔瓦卢马布改善了整体存活率和无进展存活率.
研究的目的:
- 报告来自ADRIATIC试验的患者报告结果 (PRO).
- 评估巩固杜瓦卢马布对LS-SCLC患者生活质量,功能和症状的影响.
主要方法:
- 通过使用 EORTC QLQ-C30 和 QLQ-LC13 问卷进行了评估.
- 从基线变化,时间到恶化 (TTD) 和改善率被分析为durvalumab与安慰剂手臂.
- 临床上有意义的变化被定义为≥10.0的得分变化.
主要成果:
- 没有临床上有意义的恶化在总体健康状况/生活质量,功能,或症状被观察到与安慰剂相比杜尔瓦卢马布.
- 两只手臂的恶化时间相似,除了手臂/肩膀疼痛,这种疼痛在杜尔瓦卢马布治疗后得到改善.
- 在杜尔瓦卢马布治疗组中,胸痛的改善率更高.
结论:
- 在化疗放射治疗后巩固杜尔瓦卢马布不会对患者在LS-SCLC中报告的结果产生负面影响.
- 这些发现进一步支持杜尔瓦卢马布作为对LS-SCLC的新标准护理,提高生存率而不会影响生活质量.
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