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相关概念视频

Peptide Bonds02:43

Peptide Bonds

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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
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Classical Conditioning01:18

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Associative learning, a core principle in behavioral psychology, involves forming connections between events and facilitating learned responses. This concept is vividly illustrated by classical conditioning, a process extensively studied by the Russian physiologist Ivan Pavlov. Pavlov's pioneering research on dogs' digestive systems led to the discovery that behaviors can be learned through association, laying the groundwork for classical conditioning.
Ivan Pavlov observed that dogs...
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Principles of Classical Conditioning01:23

Principles of Classical Conditioning

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Classical conditioning, as described by Ivan Pavlov, is a foundational concept in associative learning, where a neutral stimulus becomes capable of eliciting a conditioned response through association with an unconditioned stimulus. The process of acquisition, where this learning occurs, and the subsequent phenomena of contiguity, contingency, generalization, discrimination, extinction, and spontaneous recovery are crucial for a comprehensive understanding of classical conditioning.
During the...
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Classical Conditioning in Daily Life01:17

Classical Conditioning in Daily Life

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Classical conditioning, a fundamental principle of associative learning, explains various phenomena observed in daily life, such as fear development, the placebo effect, taste aversion, and drug habituation. These applications demonstrate the profound impact of associative learning on human behavior and physiological responses.
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Structures of Solids02:22

Structures of Solids

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Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
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Classical conditioning not only includes the initial pairing of stimuli but also extends to more complex forms, such as higher-order conditioning. Higher-order conditioning involves creating associations beyond the primary conditioned stimulus, resulting in a chain of conditioned responses.
Higher-order, or second-order, conditioning occurs when a neutral stimulus becomes associated with an already established conditioned stimulus through repeated pairings. For instance, if a dog has been...
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相关实验视频

Updated: Feb 3, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
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通过WDR5识别非经典WIN的结构基础.

Yang Yang1, Yan Pan1, Qingying Wang1

  • 1School of Life Sciences and Medical Engineering, Anhui University, Hefei, Anhui 230601, China.

Journal of molecular biology
|February 1, 2026
PubMed
概括
此摘要是机器生成的。

研究人员发现了WD重复含有蛋白5 (WDR5) 可以与分子结合的新方法,揭示了意想不到的灵活性. 这一发现为开发针对癌症的WDR5抑制剂提供了新的策略.

关键词:
这是WDR5的WDR5.在WIN网站上找到WIN网站.在X射线晶体学.蛋白质与蛋白质的相互作用通过结合模式的跨结合模式.

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Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
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科学领域:

  • 生物化学 生化学
  • 结构生物学 结构生物学
  • 在瘤学瘤学.

背景情况:

  • 含WD重复蛋白5 (WDR5) 是染色体修饰复合物的关键支架.
  • WDR5交互 (WIN) 位点对于WDR5与伙伴蛋白的相互作用至关重要.
  • WDR5失调与癌症有关,使WIN部位成为治疗点.

研究的目的:

  • 为了探索 WDR5 WIN 站点的新型绑定几何学,超越规范交互.
  • 调查替代WDR5识别模式的结构基础.
  • 为下一代WDR5抑制剂的设计提供信息.

主要方法:

  • 使用含有阿尔金因的探针对WDR5的高分辨率晶体结构进行确定.
  • 异热定位热量计 (ITC) 用于评估结合亲缘关系.
  • 对WIN部位和相邻的S7口袋的结的结构分析.

主要成果:

  • 确定了两种以前未被识别的类对WDR5 WIN部位的结合方式.
  • 一个结在一个扩展的构造,桥接WIN和S7站点.
  • 另一种采用了反向 (跨WIN) 方向,涉及到两个位点.
  • ITC证实了中等和特定的结合亲缘关系.

结论:

  • WDR5 WIN站点表现出显著的形状适应性.
  • WDR5的识别范围超出了正典图案,容纳了各种各样的绑定拓.
  • 这些发现为设计针对癌症治疗的WDR5抑制剂提供了一个框架,其目标是替代的结合模式和多部位参与.