预防性氧化与苏芬坦尼尔治疗经过管道动脉化学栓塞后的急性和延迟疼痛:随机对照试验与炎症生物标志物分析
Wen-Tao Wu1, Bo-Jing Xu1, Bing Li1
1Department of Anesthesiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Journal of vascular and interventional radiology : JVIR
|February 1, 2026
概括
与sufentanil相比,预防性氧化在通过导管动脉化学栓塞 (TACE) 后提供了优异的疼痛缓解. 这项研究突出了氧化的作用.
科学领域:
- 在瘤学瘤学.
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 过导管动脉化学栓塞 (TACE) 是一种常见的癌症治疗方法.
- 有效的疼痛管理对于TACE后患者的康复至关重要.
- 片类止痛药经常被使用,但它们的比较有效性需要研究.
研究的目的:
- 为了比较预防性氧化与sufentanil在治疗TACE后的急性和延迟疼痛方面的有效性.
- 评估这些止痛药对炎症标志物和患者安全的影响.
主要方法:
- 一个前性,双盲,随机试验,涉及40名接受TACE的患者.
- 患者在TACE前15分钟内接受了静脉注射氧化 (0.1mg/kg) 或苏芬坦尼尔 (0.1μg/kg).
- 在急性 (0-24小时) 和延迟 (2-7天) 阶段,使用视觉模拟尺度 (VAS) 评估疼痛强度. 还测量了炎症生物标志物.
主要成果:
- 与sufentanil (P<0.001) 相比,氧化的过程内和急性阶段疼痛得分明显较低 (P<0.001).
- 氧化还在延迟阶段 (P=0.042) 提供了更好的疼痛控制,并减少了中度疼痛发作 (P=0.047).
- 升高的干白素-6 (IL-6) 水平与延迟的疼痛相关,这表明有炎症成分.
结论:
- 预防性氧化在TACE后的急性和延迟疼痛控制中比sufentanil更有效,具有类似的安全性.
- 这些发现表明,TACE后的延迟疼痛可能具有炎症基础.
- 对阿片类药物和抗炎药物联合策略的进一步研究是有必要的.
相关概念视频
Statistical Software for Data Analysis and Clinical Trials
1.5K
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.5K
Clinical Trials: Overview
5.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K
Trial and Error and Algorithm
420
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
420
Clinical Trials
10.5K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.5K
Random Error
9.8K
Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...
9.8K
Random Variables
17.8K
A random variable is a single numerical value that indicates the outcome of a procedure. The concept of random variables is fundamental to the probability theory and was introduced by a Russian mathematician, Pafnuty Chebyshev, in the mid-nineteenth century.
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
For example, let X = the...
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
For example, let X = the...
17.8K


