身体活动改善炎症性肠病患者的生活质量:系统性审查和元分析
Emese Kasznár1,2, Barbara Csendes2,3, Dorottya Gergő2,4
1Heim Pál National Pediatric Institute, Budapest, Hungary.
Journal of cachexia, sarcopenia and muscle
|February 1, 2026
概括
结构化的体育炼显著改善了炎症性肠病 (IBD) 患者的生活质量和身体健康. 虽然在统计学上没有显著性,但运动对疾病活动和肉症有潜在的益处,这需要进一步调查.
科学领域:
- 胃肠病学和临床营养学
- 运动生理学和体育医学
背景情况:
- 患有炎症性肠病 (IBD) 的患者经常表现出体力活动减少,骨矿物质密度受损 (BMD) 和肉,增加不良结果的风险.
- 身体炼干预措施因其增强骨质量和对抗肉症的潜力而得到认可.
- 运动也可以通过释放抗炎肌基因来调节炎症.
研究的目的:
- 评估结构化体育炼对IBD诊断患者疾病活动和生活质量的影响.
- 进行前后分析,以评估与运动干预相关的变化.
主要方法:
- 在2023年11月16日进行了系统的文献搜索,包括对IBD患者结构化炼干预措施的研究.
- 结果措施包括生活质量,疾病活动,身体组成,肌肉强度,炎症标志物,有氧健身和久坐时间.
- 使用平均差异 (MD) 或标准化平均差异 (SMD) 计算效应大小,以95%的置信区间 (CI);使用MINORS工具评估偏差风险.
主要成果:
- 分析了21项涉及498名IBD患者的研究. 生活质量显示显著改善 (SMD0.55,CI0.30-0.80).
- 疾病活动得分在克罗恩病 (SMD -0.20) 和性结肠炎 (SMD -0.23) 中表现出非显著的改善.
- 观察到肌肉力量和有氧健身的显著改善,特别是VO2max (SMD1.88,CI1.34-2.43);炎症标志物显示非显著的减少.
结论:
- 定期体育活动有助于提高IBD患者的生活质量和身体健康.
- 运动干预措施有望对IBD患者的疾病活动产生积极影响,并减轻IBD患者的肉症.
- 需要进一步的研究,以充分阐明由于数据的限制,对身体组成和久坐行为的影响.
相关概念视频
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.1K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.1K
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
991
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
991
01:21Inflammatory Bowel Disease V: Surgical Management
523
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
523
01:29Inflammatory Bowel Disease IV: Pharmacological Management
610
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
610
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
742
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
742
02:42Half-life of a Reaction
39.0K
The half-life of a reaction (t1/2) is the time required for one-half of a given amount of reactant to be consumed. In each succeeding half-life, half of the remaining concentration of the reactant is consumed. For example, during the decomposition of hydrogen peroxide, during the first half-life (from 0.00 hours to 6.00 hours), the concentration of H2O2 decreases from 1.000 M to 0.500 M. During the second half-life (from 6.00 hours to 12.00 hours), the concentration decreases from 0.500 M to...
39.0K