前列腺癌的特征基于快速SHG成像的原纤维结合Denoising算法.
Jia He1, Xinpeng Huang1, Yating Fang1
1Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, China.
Journal of biophotonics
|February 1, 2026
概括
快速的深度学习无声化增强了前列腺癌 (PCa) 诊断的低信号第二波生成 (SHG) 成像. 这改善了原纤维分析,使光学组织病理学更快,更准确.
科学领域:
- 生物医学光学 生物医学光学
- 医学成像医学成像
- 计算病理学计算病理学
背景情况:
- 二次波生成 (SHG) 图像可视化原纤维,对于前列腺癌 (PCa) 诊断至关重要.
- 高信号噪声比 (SNR) SHG成像需要漫长的采集,阻碍临床应用.
- 格里森分级是PCa评估的标准,依赖于组织学特征.
研究的目的:
- 为PCa评估开发一种快速的SHG成像方法.
- 为了提高图像质量,并从低SNR的SHG数据中保存诊断特征.
- 为了实现可靠的原导向分析,并缩短获取时间.
主要方法:
- 实现了快速的SHG成像,并与深度学习的消除噪音网络 (选择性残留M-Net,SRMNet) 相结合.
- 从低SNR输入中重建了高保真度SHG图像.
- 定量评估的原对齐和 stromal 组织.
主要成果:
- 拒绝网络显著改善了SHG的图像质量.
- 保持了对定量评估至关重要的原对齐特征.
- 在低SNR条件下提取了准确的原蛋白定向指标,缩短了获取时间.
结论:
- 深度学习辅助的SHG成像为PCa中可靠的原导向分析提供了有效的策略.
- 这种方法支持开发用于癌症诊断的快速和客观的光学组织病理学.
- 增强的SHG成像通过减少采集时间,同时保持图像保真性来提高诊断可行性.
相关概念视频
Classification of Skeletal Muscle Fibers
59.5K
Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
59.5K
Trial and Error and Algorithm
420
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
420
Fibril-associated Collagen
3.4K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.4K
Collagens are the Major Structural Proteins of ECM
5.8K
Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
Connective tissue proper includes loose...
5.8K
Fiber Reinforced Concrete
396
Fiber-reinforced concrete significantly enhances the structural and nonstructural properties of traditional concrete by incorporating fibers like steel, glass, and polymers. These fibers, varying from natural ones such as sisal and cellulose to manufactured ones like polypropylene and Kevlar, are mixed into hydraulic cement with aggregates. Steel fibers, often preferred for their robustness, contribute to improved ductility, toughness, and post-cracking performance. The concrete is classified...
396
Type IV Collagen of Basal Lamina
3.1K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
A type IV collagen molecule has six alpha chains which can...
3.1K


