在大脑脊髓液中的加多布托罗尔和加多特酸的放松性在3T时
Sofia Behndig1,2, Anders Garpebring1, Daniel Dahlgren Lindström1
1Department of Diagnostics and Intervention, Biomedical Engineering and Radiation Physics, Umeå University, Umeå, Sweden.
Magnetic resonance in medicine
|February 1, 2026
概括
加多布托罗尔和加多特酸在脑脊液 (CSF) 中显示出比同位素溶液中更高的T1放松性. 在涉及加多基对比剂的T1映射研究中,建议使用特定于CSF的放松度常数.
科学领域:
- 神经成像是一种神经成像.
- 生物物理学的生物物理.
- 药理学 药理学是指药理学的学科.
背景情况:
- 在脑脊液 (CSF) 中精确测量基于加多的对比剂 (GBCA) 的T1放松性对于先进的神经成像技术至关重要.
- 了解淋巴系统和CSF流动动力学取决于使用T1映射进行精确的量化.
- 内注射GBCA需要了解它们在CSF环境中的行为.
研究的目的:
- 为了确定人脑脊髓液 (CSF) 中的gadobutrol和gadoteric acid在3Tesla (3T) 磁共振成像 (MRI) 场强度中的T1放松性.
- 提供必要的数据,支持对人类脑脊液流动和淋巴系统功能的研究.
- 为了验证使用T1映射技术在GBCAs的导管内注射后的使用.
主要方法:
- 放松度的测量是使用含有腰部CSF和同位素溶液的幻影进行的.
- 用B1校正的可变翻转角度方法分析了gadobutrol和gadoteric酸样本.
- 在两个不同的3T核磁共振扫描仪上重复扫描,以评估扫描仪间的可变性,并评估CSF和同位素溶液之间的差异.
主要成果:
- 在CSF和对gadobutrol和gadoteric acid的同位素溶液之间观察到T1放松度的显著差异.
- 与同位素溶液 (2.352.74 L mmol−1 s−1) 相比,加多布托罗尔在CSF (3.023.63 L mmol−1 s−1) 中表现出更高的放松性.
- 加多特酸还显示了CSF (2.472.91 L mmol−1 s−1) 与同位素溶液 (2.372.8 L mmol−1 s−1) 的放松性更高,在扫描仪之间的T1放松率中观察到18%的缩放差异.
结论:
- 在CSF中,GBCA的T1放松性明显高于标准同位素溶液中,特别是对于gadobutrol.
- 在MRI扫描仪之间的放松度的系统差异可能可以使用从基线CSF T1时间获得的缩放因子来减轻.
- 建议在CSF环境中使用GBCA进行准确的T1映射研究时使用特定于CSF的放松度常数.
相关概念视频
Cerebrospinal Fluid
5.9K
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
5.9K
Relaxation of Skeletal Muscles
5.9K
The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
5.9K
The Fluid Mosaic Model
178.1K
The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.
178.1K
Classification of Skeletal Muscle Relaxants
3.1K
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
3.1K
Skeletal Muscle Relaxants: Therapeutic Uses
970
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
970
Skeletal Muscle Relaxants: Adverse Effects
824
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
824


