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Updated: Feb 3, 2026

Synthesis of a Deuterated Standard for the Quantification of 2-Arachidonoylglycerol in Caenorhabditis elegans
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侧链化2α-[2-(Tetrazol-2-yl) ethyl]-1α,25-dihydroxyvitamin D3类似物和初步生物活动的综合合成

Fumihiro Kawagoe1, Sayuri Mototani1, Yuki Okamoto2

  • 1Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.

Chemical & pharmaceutical bulletin
|February 1, 2026
PubMed
概括

新的维生素D类似物与侧链修饰显示增强的维生素D受体 (VDR) 结合和活性. 这些新型化合物还显示出对代谢分解的抗性增加,这表明它们具有治疗潜力.

关键词:
这是一架AH-1飞机.在 CYP24A1 中.维他命D3的类似物综合合成是一种合成.交易活化 交易活化维生素D受体是维生素D的受体.

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All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...
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