[在儿童固体瘤患者中使用plerixafor进行干细胞调动:单中心研究]
Hiroki Yoshihara1, Miho Ashiarai1, Rintaro Ono1
1Department of Pediatrics, St. Luke's International Hospital.
[Rinsho ketsueki] The Japanese journal of clinical hematology
|February 1, 2026
概括
普莱里克萨福有效地调动小儿固体瘤患者的造血干细胞,用于自身移植. 这项研究证实了其在日本的安全性和有效性,支持其在儿科干细胞移植环境中的使用.
科学领域:
- 血液学 血液学 血液学
- 儿科瘤学 儿科瘤学
- 干细胞移植 干细胞移植
背景情况:
- 自主外周血液干细胞 (PBSC) 采集在化疗后患有固体瘤的儿科患者中通常很困难.
- 普莱里克萨福 (Plerixafor) 是一种血造干细胞调动剂,用于这些具有挑战性的病例.
- 关于在日本为儿科患者使用plerixa的报告有限.
研究的目的:
- 评估plerixafor在患有固体瘤的儿科患者的干细胞调动中的疗效和安全性.
- 评估实现目标CD34阳性细胞剂量用于自身移植的可行性.
- 记录与plerixa相关的不良事件,以便在这个人群中使用.
主要方法:
- 进行了一项单一中心的回顾性观察研究.
- 8名患有固体瘤的儿科患者在2015年至2024年期间接受了9次plerixa的动员尝试.
- 分析了细胞采集,移植成功和不良事件的数据.
主要成果:
- 收集的CD34阳性细胞数的中位数为10.8×10^6/kg.
- 在所有病例中都观察到成功达到对象细胞剂量用于自身移植.
- 副作用是轻微的和短暂的,包括头痛,肝酶升高和腹;没有发生严重事件.
结论:
- 普莱里克萨福尔在患有固体瘤的儿科患者中显示出有效性和良好的耐受性.
- 它的有效性在新诊断的和复发的疾病状态中是一致的.
- 普莱里克萨福在日本儿科移植机构中代表了干细胞调动的有价值选择.
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