患有抑郁症的老年人潜在不合适的药物和治疗坚持:基于人口的队列研究
Diego Infante-Ventura1, Benjamín Rodríguez-Díaz2, Alejandra Abrante Luis2
1Canary Islands Health Research Institute Foundation (FIISC), Tenerife, Spain; Evaluation Unit (SESCS), Canary Islands Health Service (SCS), Tenerife, Spain; Spanish Network of Agencies for Health Technology Assessment for the National Health Service (RedETS), Spain; Department of Clinical Psychology, Psychobiology and Methodology, University of La Laguna, Tenerife, Spain.
International psychogeriatrics
|February 1, 2026
概括
在西班牙,患有抑郁症的老年人中,潜在不合适的药物 (PIM) 非常普遍,增加了不坚持抗抑郁药物治疗的风险. 年轻的老年人,女性和患有并发症的人更有可能接受PIMs.
科学领域:
- 老年病的医生 老年病的医生
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 晚年抑郁症影响着相当一部分老年人群.
- 潜在不合适的药物 (PIMs) 是老年人药物治疗中的一个问题.
- 坚持抗抑郁药治疗对于管理老年人的抑郁症至关重要.
研究的目的:
- 确定西班牙患有抑郁症的老年人中PIM的患病率.
- 分析PIM疗法与抗抑郁药治疗坚持之间的关联.
- 在这个队列中确定与PIM处方相关的因素.
主要方法:
- 在西班牙 (2013-2021) 的加拿大群岛进行了回顾性,基于人口的队列研究.
- 利用了来自12272名65岁以上患有抑郁症的患者的现实数据.
- 使用Beers,STOPP和PRISCUS标准评估PIM流行情况;通过后勤回归分析了遵守情况.
主要成果:
- 在接受抗抑郁药治疗的患者中,PIM患病率从73%到89%不等.
- 较高的PIM风险与年轻的年龄,女性性别以及增加的精神病/护理并发症有关.
- 不遵守规则的风险随着规定的PIM数量的增加而持续增加.
结论:
- 在患有抑郁症的西班牙老年人中,PIM的患病率很高,影响了治疗的坚持.
- 年轻的老年人,女性和患有并发症的人面临着更大的PIM暴露风险.
- 需要进一步的研究,以充分阐明这个人群中的PIM-坚持关系.
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