饮食高级糖化终端产品 (dAGEs):健康长寿的病原和营养策略-一个批判性的观点
Paola Russo1, Ivana Sirangelo2, Alfonso Siani3
1Institute of Food Sciences, CNR, Avellino, Italy; Department of Precision Medicine, University of Campania "L. Vanvitelli", Naples, Italy.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|February 1, 2026
概括
从饮食中获得的高级甘化终产品 (AGEs) 加快了衰老和疾病. 通过方法减少饮食AGE (dAGEs) 可能会改善健康,但需要更多的人体试验.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 老年学是指老年学的学科.
背景情况:
- 先进的甘化终产物 (AGEs) 通过梅拉德反应形成,将代谢功能障碍,疾病和衰老联系起来.
- 来自加工食品的饮食AGE (dAGEs) 对身体的AGE负载有显著的贡献.
- AGEs是活跃的病因因素,而不仅仅是生物标志物,驱动病理.
研究的目的:
- 批判性地评估AGE作为病理学的积极驱动因素的证据.
- 评估AGE的双重机制:结构损伤和RAGE介导的炎症.
- 突出饮食中AGE在加速慢性疾病和衰老中的作用.
主要方法:
- 关于AGE和RAGE的当前科学文献的审查.
- 对内源性与外源性AGE形成途径的分析.
- 对减轻dAGE形成的营养策略的评估.
主要成果:
- 通过RAGE,AGE损害结构完整性,并通过RAGE诱导氧化应激和炎症.
- 高脂肪,高蛋白质的食物煮在高,干燥的热量增加AGE负载.
- 修改 (湿热,酸性成分) 减少了dAGE的形成.
结论:
- 限制dAGE是一种潜在的预防性健康营养干预措施.
- 需要长期的人体干预试验来证实dAGE限制对健康的益处.
- 进一步的研究应该量化dAGE限制对健康寿命和寿命的独立贡献.
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