与药物治疗过程属性相关的健康实用值:系统性审查和元分析
Yun Liu1, Xinyu Du1, Zheng Rong1
1School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, China.
Health and quality of life outcomes
|February 1, 2026
概括
患者对治疗过程属性的偏好,如给药途径和持续时间,显著影响健康效用. 注射途径和更长的施用时间独立地减少了效用,而频率效应则因途径而混.
科学领域:
- 药物经济学 药物经济学
- 卫生经济学 卫生经济学
- 与健康相关的生活质量 (HRQoL)
背景情况:
- 当临床形状相似时,患者对治疗过程属性的偏好 (例如,给药途径,频率,时间) 对于坚持和HRQoL至关重要.
- 关于这些属性的实用性影响的现有研究是异质的,经常混,阻碍了对独立效应的精确量化.
- 了解这些独立效应对于准确的药物经济评估和以患者为中心的治疗决策至关重要.
研究的目的:
- 系统地审查和解构治疗过程属性对健康效用影响的评估中的混偏见.
- 用多变量元回归来分离给药途径,频率和持续时间对健康效用值的独立影响.
- 通过控制关键混因素,为药物经济评估提供强有力的证据.
主要方法:
- 在主要数据库 (PubMed,Cochrane,Web of Science,EBSCO) 中按照PRISMA指南进行系统的文献搜索,直到2024年12月.
- 包含与药物治疗过程属性相关的健康实用值 (0-1级) 报告的原始研究.
- 使用随机效应模型分析失用值,并构建多变量元回归模型以对疾病类型和受访者群体进行控制.
主要成果:
- 包含了19项研究,包括81个实用值. 注射途径 (与口服) 显著降低了效用 (β = -0.092,p < 0.001).
- 超过1小时的服用时间也显著降低了效用 (β = -0.172,p < 0.005). 疾病的严重程度是主要的预测因素,瘤显示的效用低于代谢条件.
- 在未经调整的分析中,一个明显的"频率悖论"被确定为通过给药途径混的统计文物;没有独立于频率的影响.
结论:
- 注射剂的使用和长时间的使用时间是健康不良的重要独立驱动因素.
- 剂量频率的感知负面影响是给药途径的混因素,而不是独立的影响.
- 在药物经济评估中,采用整体的多变量方法至关重要,以避免由于混偏差而导致错误的结论.
更多相关视频
08:36Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
1.2K
06:26Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
Published on: November 27, 2019
77.6K
相关概念视频
Biodiversity and Human Values
17.1K
Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.
17.1K
Attribution Theory
13.8K
Behavior is a product of both the situation (e.g., cultural influences, social roles, and the presence of bystanders) and of the person (e.g., personality characteristics). Subfields of psychology tend to focus on one influence or behavior over others. Situationism is the view that our behavior and actions are determined by our immediate environment and surroundings. In contrast, dispositionism holds that our behavior is determined by internal factors (Heider, 1958).
13.8K
Fundamental Attribution Error
13.8K
According to some social psychologists, people tend to overemphasize internal factors as explanations—or attributions—for the behavior of other people. They tend to assume that the behavior of another person is a trait of that person, and to underestimate the power of the situation on the behavior of others. They tend to fail to recognize when the behavior of another is due to situational variables, and thus to the person’s state. This erroneous assumption is...
13.8K
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
329
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
329
Attribution
287
In social interactions, individuals frequently seek to understand the motivations and causes behind others' behaviors. This fundamental aspect of social perception, known as attribution, plays a crucial role in shaping interpersonal relationships and guiding future actions. Attribution refers to the cognitive process through which people infer the reasons behind others' behaviors, allowing them to assess character traits, intentions, and situational influences.Attribution Theory and Its...
287
Professional Values
10.7K
Nurses are responsible for caring for patients during birth, death, illness, and healing. Professional values guide the decisions and actions that nurses make in their careers. If nurses know the decisions and actions to take, providing patients with exceptional care is possible.
The values that are the foundation of the nursing profession are altruism, autonomy, human dignity, and social justice.
First, altruism refers to the concern for the welfare and well-being of others without personal...
The values that are the foundation of the nursing profession are altruism, autonomy, human dignity, and social justice.
First, altruism refers to the concern for the welfare and well-being of others without personal...
10.7K
