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评估治疗性失声症的肉毒素疗法的效果:一个奥地利-德国注册表

Berit Schneider-Stickler¹, Gerd Fabian Volk², Oliver Galvan³

¹Department of Otorhinolaryngology, Division of Phoniatrics-Logopedics, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria. berit.schneider@meduniwien.ac.at.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

|February 1, 2026

概括

肉毒神经毒素 (BoNT) 注射可以改善性失声症 (SD) 的症状,如语音紧张和,但不能恢复正常的语音质量. 患者报告的结果,如语音障碍指数 (VHI-9i),比客观的语音措施更能反映治疗成功.

科学领域:

神经学神经学
耳鼻喉科耳鼻喉科耳鼻喉科
语音语言病理学语言病理学

背景情况:

性听力障碍 (SD) 是一种神经语音障碍,其特点是不自发的肌肉影响语音产生.
肉毒神经毒素 (BoNT) 注射是SD的常见非标签治疗方法,旨在减少肌肉过度活动.
缺少SD诊断和治疗评估的标准化结果措施,使证据评估复杂化.

研究的目的:

评估奥地利和德国对SD症状的BoNT治疗结果.
通过选择的主观和客观语音参数来评估BoNT的有效性.
将患者报告的结果与治疗后客观语音测量结果进行比较.

主要方法:

一个多中心注册表包括41名SD患者接受BoNT类型A注射.
收集的数据包括人口和治疗特征,副作用和语音评估 (RBH尺度,VRP,数,语音应变).
患者报告的结果 (VHI-9i,CPIB,发音力VAS) 与治疗后一个月的基线测量结果进行了比较.

主要成果:

博恩特治疗显著减少了语音和张力,并将语音努力提高了约50%.
患者报告的结局显示改善,VHI-9i和CPIB分类从中度到轻度降低.
虽然像Jitter-%和失声严重程度指数 (DSI) 这样的客观参数有所改善,但它们并没有正常化. 歌声参数没有受到影响.

结论:

BoNT注射有效缓解SD症状,如和语音应变,并改善患者报告的语音障碍.
该研究强调了像VHI-9i和CPIB这样的患者报告结果指标 (PROM) 在评估SD的BoNT治疗有效性的重要性.
虽然BoNT治疗有益,但它不能完全恢复SD患者的正常语音质量.

关键词:

化工化工化工化工化工化工化失声症 (Dysphonia) 是一种听力障碍.喉 dystonia 喉 dystonia 喉 dystonia 喉 dystonia 喉 dystonia 喉 dystonia 喉 dystonia 喉 dystonia 喉 dystonia 喉 dystonia 喉 dystonia 喉 dystonia 喉 dystonia 喉 dystonia 喉 dystonia 喉 dystonia 喉 dystonia 喉 dystonia 发生的数量.声音的压力声音的压力

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