用Upadacitinib治疗的反应性关节炎逐渐消失
Jiawen Zhang1, Jingtao Zhang1, Fanping Yang1
1Department of Dermatology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China.
概括
反应性关节炎 (ReA) 是一种具有挑战性的后感染性炎症状况. 作为Janus 激酶1 (JAK1) 抑制剂的阿巴达西丁 (Upadacitinib) 在一个耐火的ReA病例中显示出快速和持续的改善.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 反应性关节炎 (ReA) 是一种后感染性炎症性疾病.
- 耐药的ReA病例带来了重大的治疗挑战.
- 该患者HLA-B27阳性,并呈现了三重性关节炎,结膜炎和平衡炎,以及牛皮形皮肤病变.
研究的目的:
- 报告一种耐火性反应性关节炎病例.
- 评估乌帕达西提尼布在治疗严重的 ReA 症状中的疗效.
- 探索Janus激酶1 (JAK1) 抑制在ReA中的作用.
主要方法:
- 一名20岁的男性患者患有耐火性HLA-B27阳性ReA,接受了乌帕达西提尼布 (15毫克/天) 治疗.
- 包括抗生素,NSAID,皮质类固醇和硫素在内的传统疗法无效.
- 对关节,眼睛和皮肤症状进行疾病活动监测.
主要成果:
- 在三周内,Upadacitinib治疗导致关节炎,结膜炎和皮肤病变的快速改善.
- 皮质类固醇的治疗成功地逐渐减少,并且在没有疾病复发的情况下停止使用.
- 缓解维持了超过三个月,使用降低剂量的upadacitinib.
结论:
- 乌帕达西丁 (Upadacitinib) 显示出作为耐火性反应性关节炎的治疗选择的潜力.
- 抑制JAK1可能在ReA的发病过程中发挥关键作用.
- 这一案例表明,upadacitinib是对严重和耐治疗的REA的有前途的治疗方法.
相关概念视频
02:07Tumor Progression
7.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.4K
00:42Cross-reactivity
33.0K
Overview
33.0K
01:18Reactivity of Enols
4.1K
Enols are a class of compounds where a hydroxyl group is attached to a carbon–carbon double bond, which implies that it is a vinyl alcohol. A carbonyl compound with an α hydrogen undergoes keto–enol tautomerism and remains in equilibrium with its tautomer, the enol form. Usually, the keto tautomer is present in a higher concentration than the enol tautomer due to the higher bond energy of C=O compared to C=C. Moreover, the direction of the keto–enol equilibrium is...
4.1K
01:23Reactivity of Enolate Ions
3.3K
Enolate ions are formed by the acid–base reaction of a carbonyl compound with a base. This leads to deprotonation of the α hydrogen atom, leading to a resonance-stabilized enolate ion where one of the contributing structures is an oxyanion, which imparts additional stability. Therefore, the proton on the α carbon is more acidic in nature than that of other sp3-hybridized C–H bonds but less acidic than those in O–H bonds where the negative charge in the conjugate...
3.3K
03:03mTOR Signaling and Cancer Progression
4.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.8K
01:11Radical Reactivity: Overview
2.8K
Radicals, the highly reactive species, gain stability by undergoing three different reactions. The first reaction involves a radical-radical coupling, in which a radical combines with another radical, forming a spin‐paired molecule. The second reaction is between a radical and a spin‐paired molecule, generating a new radical and a new spin‐paired molecule. The third reaction is radical decomposition in a unimolecular reaction, forming a new radical and a spin‐paired...
2.8K