生物矩阵中的度和肌缩性侧面硬化症 (ALS):系统性审查和元分析
Maryam Salehcheh1,2, Mehrad Nikravesh3, Saeed Aghebat-Bekheir4
1Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
概括
(Mn) 含量在肌缩后侧硬化症 (ALS) 患者和健康对照人群之间没有显著差异. 这次系统性审查没有发现证据表明的度与ALS有关,这表明可能涉及其他因素.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- (Mn) 是一种具有神经毒性潜力的微量元素.
- 它在神经退行性疾病,如肌缩侧面硬化症 (ALS) 中的作用尚不清楚.
- 研究ALS中Mn水平对于了解疾病机制至关重要.
研究的目的:
- 系统地审查和对ALS患者的度与对照者的现有研究进行元分析.
- 为了确定这些群体之间是否存在Mn水平的显著差异.
- 确定当前研究中异质性的潜在来源.
主要方法:
- 在主要科学数据库 (PubMed,EMBASE,科学网,Scopus) 进行系统搜索.
- 包括观察性研究,比较ALS患者和健康对照者的Mn度.
- 使用随机效应模型进行元分析,以汇集标准化平均差异 (SMD) 并评估异质性 (I2统计) 和出版偏差 (Egger测试).
主要成果:
- 分析了12项涉及446例ALS病例和652例对照病例的研究.
- 在ALS患者和对照人群之间没有发现Mn度的显著差异 (SMD=0.05;95%CI: -0.20至0.30).
- 小组分析和元回归表明分析方法有助于异质性,但在生物矩阵中没有出现一致的模式.
结论:
- 周围的度在患有ALS的人和健康对照人之间没有显著差异.
- 目前的证据不支持外围含量与ALS之间的直接关联.
- 未来的研究应该专注于纵向研究,中枢神经系统 (CNS) 向的方法,以及用于Mn评估的标准化分析协议.
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