从信号通路到组合疗法:生物活性化合物对抗癌症干细胞
P S V V Charan1, Nikitha S Pai1, Nivruthi A Naik1
1Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Clappana, 690525, Kerala, India.
Stem cell reviews and reports
|February 1, 2026
概括
自然生物活性化合物在向癌症干细胞 (CSCs) 方面表现有前途,以防止复发和转移. 这些化合物提供一种低毒性方法,以提高癌症治疗的疗效和改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 癌症干细胞 (CSCs) 驱动瘤复发,转移和治疗耐药性.
- 准CSC对于实现可持续的癌症治疗反应和改善无疾病生存率至关重要.
- 天然生物活性化合物为CSC向治疗提供了一个有希望的,低毒性的途径,因为它们具有多途径抑制能力.
研究的目的:
- 审查目前利用生物活性化合物用于癌症干细胞根除的战略.
- 探索这些化合物的作用机制,临床前/临床证据和组合治疗潜力.
- 讨论与生物活性化合物结合的互补策略,如差异化疗法,代谢向和免疫调节.
主要方法:
- 对针对CSC的生物活性化合物的临床前和临床研究的文献综述.
- 通过这些化合物调节的主要信号通路 (Wnt/β-catenin,Notch,Hippo-YAP/TAZ,Hedgehog,PI3K/Akt/mTOR,NF-κB) 的分析.
- 基于纳米技术的输送系统的探索,以提高疗效和瘤积累.
主要成果:
- 生物活性化合物可以诱导亡,抑制上皮层-介质细胞过渡 (EMT),并破坏CSC.
- 这些化合物可以通过准CSC新陈代谢和阻断自,使瘤对常规化疗重新敏感.
- 纳米技术提高了生物活性化合物的稳定性,生物可用性和瘤积累.
结论:
- 生物活性化合物代表了针对CSC的可行策略,单独或在组合疗法中.
- 与生物活性化合物相结合的补充方法可以克服CSC的耐药性.
- 对结合,多目标,基于CSC的策略的进一步研究具有改善癌症治疗结果和预防复发的巨大潜力.
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