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吸入性胰岛素的肺安全性和临床考虑:综合性审查
Janet B McGill1, Oscar M Mayer2
1Division of Endocrinology, Metabolism and Lipid Research, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA.
Diabetes technology & therapeutics
|February 1, 2026
概括
科技界®胰岛素 (TI) 是唯一可用的快速起作用的吸入性胰岛素. 有证据表明,TI对1型和2型糖尿病患者是安全的,只有轻微的,短暂的咳作为常见的副作用.
科学领域:
- 肺部医学 肺部医学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 第一个吸入性胰岛素Exubera®于2006年获得FDA批准,但在2007年被撤回.
- 科技界®胰岛素 (TI) 是目前唯一可用的快速起作用的吸入性胰岛素,由FDA批准.
研究的目的:
- 为解决与Technosphere®胰岛素 (TI) 相关的肺安全问题.
- 提供关于TI在1型和2型糖尿病患者的安全性的证据.
主要方法:
- 关于TI疗效和不良事件的最新研究的综述.
- 对糖尿病人群临床试验中的安全数据的分析.
主要成果:
- TI已经证明有效,除了轻微的短暂咳之外,没有显著的不良事件.
- 与TI相关的轻度咳通常会随着时间的推移而减弱.
结论:
- TI是一种安全有效的快速起作用的吸入胰岛素,用于治疗1型和2型糖尿病.
- 证据支持TI的肺安全性,即使是长期使用.
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