类固醇对人类耳阻抗的影响:系统性审查
Alex W Yang1, James J Pierre1, Jessica L Lewis-Cruz2
1Department of Otolaryngology Head and Neck Surgery, Walter Reed National Military Medical Center, Bethesda, MD.
概括
术后的类固醇输送,特别是局部方法,如入内和内内注射,可以减少植入后的内阻抗. 系统性类固醇对耳阻抗没有显著影响.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经外科 神经外科
- 药理学 药理学是指药理学的学科.
背景情况:
- 耳植入是严重听力损失的常见治疗方法.
- 管理手术后的炎症及其对耳植入物性能的影响至关重要.
- 类固醇通常用于外科手术,但它们对耳阻抗的影响需要澄清.
研究的目的:
- 系统地审查外科手术期间使用类固醇对进行耳植入的患者耳阻抗的影响.
- 为了比较不同类固醇输送方法对耳阻抗结果的影响.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 包括比较带有和没有外科手术期间类固醇的耳阻抗的研究.
- 提取关于类固醇施用 (方法,时间,剂量) 和耳阻抗的数据.
主要成果:
- 分析了12项研究,检查了肠,内,药物排泄电极和静脉/口服类固醇路径.
- 九项研究表明,外科手术期间使用类固醇与改变的耳阻抗之间存在显著的关联.
- 局部类固醇输送 (内,内,药物释放电极) 显示阻抗降低长达1年,而口服/静脉类固醇没有.
结论:
- 通过入,内或药物释放电极传递局部外科手术期间的类固醇可以减少植入后的耳阻抗.
- 口服类固醇的使用似乎没有影响耳阻抗.
- 需要进一步的研究才能充分理解类固醇使用与耳阻抗之间的关系.
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