对于树木蛇尾巴长度进化的基因组适应
Zeng Wang1,2,3,4, Wei Wu1,3, Fuyuan Shen5
1Mountain Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610213, China.
Molecular biology and evolution
|February 2, 2026
概括
蛇尾延长为树木生活进化了多次. 基因组分析揭示了控制轴向生长的基因的加速进化和调控元素的保留变化,为理解这一关键适应提供了一个框架.
科学领域:
- 进化生物学 进化生物学
- 基因组学就是基因组学.
- 发展生物学 发展生物学
背景情况:
- 蛇的树木适应涉及形态上的创新,如延长的尾巴,以改善树枝的抓取.
- 在适应树木环境的蛇中,反复出现尾巴延长的遗传基础在很大程度上是未知的.
研究的目的:
- 为了研究树木蛇中反复出现的尾巴延长的基因组基础.
- 识别与轴延长和尾巴发育相关的基因和调控元素.
主要方法:
- 祖先状态的重建,以确定树木现实和尾巴延长的独立进化.
- 绿猫蛇 (Boiga cyanea) 的基因组组合和与亚洲葡萄蛇 (Ahaetulla prasina) 的比较基因组学.
- 对基因进化的分析,包括加速进化和索米托基因的积极选择,以及对保存的非索基因元素 (CNEs) 的检查.
主要成果:
- 树木和尾巴延长在多个蛇系中独立演变.
- 在与索米特特异性相关的基因中发现了加速进化,在HES7和TBX18中具有积极选择.
- 在树木蛇中观察到LOXL3中保存的氨基酸替代和调节GDF11-LIN28-HOX13通路的CNEs的融合分歧.
- 功能性分析证实了不同CNE的监管活动发生变化.
结论:
- 索米托生成基因和调节元件的基因组变化有助于蛇的轴延长和尾巴长度进化.
- 基因组层面的融合进化是树木蛇中尾巴延长的反复适应的基础.
- 这项研究为了解树木专业化如何驱动蛇的尾巴长度进化提供了一个基因组框架.
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