转换铜 (II) - 催化过程用于选择性获取C3-imidazolyl-和Pyridylquinoxalin-2 (H) -one
S Banuprakash Goud1, Raju L Dhakar1, Sampak Samanta1
1Department of Chemistry, Indian Institute of Technology Indore, Simrol, Indore, Madhya Pradesh 453552, India.
The Journal of organic chemistry
|February 2, 2026
概括
一种新的CuBr2催化反应从简单的前体中合成C3-imidazoylquinoxalinones. 用Cu(OAc) 2取代CuBr2,可以得到C3-pyridylquinoxalinones,而DMSO则作为C-H来源.
科学领域:
- 有机合成 有机合成
- 药用化学 医学化学
- 异环化学 异环化学
背景情况:
- 昆素是药物化学中重要的异环基架.
- 功能化昆素的高效合成仍然是一个挑战.
- 交叉脱配合和氧化反应提供了新的合成途径.
研究的目的:
- 开发一种新型的伪四组分反应,用于合成C3功能化诺.
- 探索DMSO作为溶剂和C-H来源在异环合成中的使用.
- 通过进一步的转化来证明获得的昆素的合成效用.
主要方法:
- 一种化铜 (CuBr2) 催化的伪四组分反应,涉及DMSO中的素-2--1-,乙和硫酸盐.
- 通过使用铜 (II) 乙 (Cu (OAc) 2) 来改变反应路径来修改反应.
- 合成的昆素衍生物的后续化学转化.
主要成果:
- 成功合成C3-imidazoylquinoxalinones在良好的产量通过一个级联的交叉脱联结,Kornblum氧化和aza-cyclization.
- 选择性合成高价值的C3-pyridylquinoxalinones,通过用Cu(OAc) 2替换CuBr2,使用DMSO作为C-H来源.
- 通过将它们转化为3-(imidazo[1,2-a]pyrazin-3-yl) quinoxalinone和2-sulfonylquinoxalines来证明合成化合物的多功能性.
结论:
- 已经建立了一个简单有效的合成途径,以获得C3-imidazoyl-和C3-pyridylquinoxalinones.
- 开发的方法为构建复杂的异环结构提供了实用方法.
- 合成的昆素衍生物作为进一步化学加工的有价值的中间体.
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