双相情绪障碍和多动症多动症的认知和职业功能:并发症的影响
Anna Luisa Klahn1, Andreas Göteson1, Elin Hörbeck1
1Department of Psychiatry and Neurochemistry, https://ror.org/01tm6cn81Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
The British journal of psychiatry : the journal of mental science
|February 2, 2026
概括
患有双相情感障碍和ADHD的个体表现出显著的认知和功能障碍,特别是在工作记忆中. 执行功能,受遗传学对教育成就的影响,预测双相情感障碍的职业结果.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 双极性障碍 (BD) 和注意力缺陷/多动性障碍 (ADHD) 分享重叠的症状和认知缺陷.
- 大约20%的BD个体也符合ADHD (BD + ADHD) 的标准,可能会经历更严重的损伤.
研究的目的:
- 与健康对照人群相比,描述BD,ADHD和BD+ADHD患者的认知概况.
- 研究认知功能与职业功能之间的关系.
- 研究BD,ADHD和教育成就的认知功能和多基因分数 (PGS) 之间的关联.
主要方法:
- 观察性研究涉及477名BD患者 (78名BD+ADHD患者),59名ADHD患者和171名健康对照人群.
- 标准化神经心理测试,包括IQ和学校成绩用于认知能力评估.
- 职业功能经过横截面评估,并通过5年注册后续进行评估; PGS数据可用于子集.
主要成果:
- 所有患者群体的认知表现明显低于健康对照组.
- 与单独服用BD组相比,BD+ADHD组的工作记忆和职业功能更差.
- 较差的执行功能和年龄较大预测BD的职业成果降低;教育成就与认知正相关.
结论:
- 患有BD + ADHD的子组在工作记忆和功能方面表现出不成比例的损伤.
- 执行职能是BD职业成果的关键预测因素,部分受遗传因素对教育成就的影响.
- 考虑到ADHD并发症和认知特征对于双相情感障碍的预后和干预至关重要.
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