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通过可编程纳米囊-水凝平台增强化学免疫疗法,用于序列性瘤微环境重塑

Xiaoyan Qin^1,2, Yushu Wang³, Yunhao Feng¹

¹State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, China.

Advanced materials (Deerfield Beach, Fla.)

|February 2, 2026

概括

这项研究引入了用于癌症治疗的新丝水凝平台,将化疗和免疫疗法结合起来,以获得持续的抗瘤反应. 可编程的输送系统增强了免疫细胞的活动和瘤微环境中的持久性.

科学领域:

生物医学工程生物医学工程
癌症研究癌症研究
免疫治疗是一种免疫疗法.

背景情况:

持久的癌症免疫疗法反应取决于强大的抗瘤免疫力和在免疫抑制瘤微环境 (TME) 中持续的免疫压力.
常规化疗与免疫疗法相结合,面临着诸如不可预测的反应持续时间和全身毒性等挑战.

研究的目的:

开发一个可编程的输送平台,整合化疗和免疫检查点封锁,以加强癌症治疗.
通过控制瘤部位的药物释放动力学来克服当前化疗-免疫疗法组合的局限性.

主要方法:

一个带有pH响应的纳米囊的丝纤维蛋白水凝平台被设计用于控制的,时间空间释放氧沙 (化疗) 和抗PD-L1 (免疫疗法).
杆分子重量差异的差异释放:快速扩散的oxaliplatin和反PD-L1纳米囊的逐渐降解在TME.
在小鼠乳腺瘤模型中评估平台的疗效,评估瘤细胞免疫性,TME调节,抗瘤反应和T细胞记忆.

主要成果:

该平台通过oxaliplatin释放成功启动了瘤内在的免疫性压力.
通过从纳米囊中逐渐释放抗PD-L1来实现免疫检查点的持续参与.
综合方法将非免疫原性瘤细胞转化为免疫原性状态,调节TME,并促进持久的抗瘤反应.
在接受治疗的小鼠模型中观察到长期中央记忆T细胞的持久性.

结论:

这种多功能丝水凝平台为下一代化疗-免疫疗法组合提供了可通用的策略.
化学疗法和免疫疗法的控制时间释放可以克服当前治疗方法的局限性,并改善持久的抗瘤免疫力.

关键词:

适应pH值的纳米囊可以编程的药物输送.序列化疗-免疫疗法.持续的检查点参与.瘤微环境重塑的重塑

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