新生儿维生素D状况和5岁后的喘风险:一项丹麦基于人口的队列研究
Xiaoqin Liu1, Zhihong Zhu1, Bo Chawes2,3
1NCRR-The National Centre for Register-Based Research, Department of Public Health, Aarhus University, Aarhus, Denmark.
概括
新生儿维生素D水平和维生素D结合蛋白与喘风险无关. 对维生素D状况的遗传倾向也不会增加儿童喘风险.
科学领域:
- 儿科过敏和免疫学
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 新出现的证据表明,维生素D在肺部早期发育中可能起作用.
- 然而,关于维生素D与晚期喘风险之间的关联现有的流行病学数据仍然没有确定性.
- 这项研究调查了新生儿维生素D状态与喘风险之间的关系.
研究的目的:
- 检查新生儿25-氧维生素D (25(OH) D和维生素D结合蛋白 (DBP) 水平与患喘风险的相关性.
- 评估25-OH) D,DBP和喘遗传预测因子对喘风险的影响.
主要方法:
- 一项基于人口的队列研究利用了来自iPSYCH2012研究的数据,包括1991年至2005年间出生在丹麦的个人.
- 新生儿25(OH) D和DBP度从干燥的血液斑点中测量.
- 喘诊断和处方在5岁后被记录下来,Cox回归用于通过多基因分数 (PGS) 分析关联和遗传责任.
主要成果:
- 在新生儿25OH) D或DBP水平与患喘的风险之间没有发现显著的关联.
- 对于25(OH) D和DBP的多基因评分与喘风险增加没有相关性.
- 相反,较高的喘多基因分数与喘风险增加密切相关.
结论:
- 新生儿维生素D状况,包括25OH) D和DBP水平,没有明显的与喘风险相关.
- 正如多基因分数所指出的,影响维生素D状态的遗传责任似乎不会增加喘风险.
- 这些发现有助于理解维生素D,遗传学和喘发育之间的复杂相互作用.
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